A review of induced pluripotent stem cell, direct conversion by trans-differentiation, direct reprogramming and oligodendrocyte differentiation

被引：30

作者：

Prasad, Ankshita ^{[1
]}

Manivannan, Janani ^{[2
]}

Loong, Daniel T. B. ^{[1
]}

Chua, Soo M. ^{[1
]}

Gharibani, Payam M. ^{[3
]}

All, Angelo H. ^{[1
,2
,3
,4
,5
,6
,7
]}

机构：

[1] Natl Univ Singapore, Singapore Inst Neurotechnol, Div Neurol, Dept Orthopaed Surg Biomed Engn & Med, Singapore 117548, Singapore

[2] Natl Univ Singapore, Med, Div Neurol, Dept Orthoped Surg, Singapore 117548, Singapore

[3] Johns Hopkins Sch Med, Dept Biomed Engn & Neurol, Baltimore, MD USA

[4] Natl Univ Singapore, Div Neurol, Dept Med, Singapore 117548, Singapore

[5] Natl Univ Singapore, Div Neurol, Dept Biomed Engn & Med, Singapore 117548, Singapore

[6] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA

[7] Natl Univ Singapore, Singapore Inst Neurotechnol, Ctr Life Sci, 28 Med Dr,05-COR, Singapore 117456, Singapore

来源：

REGENERATIVE MEDICINE | 2016年 / 11卷 / 02期

关键词：

direct conversion; direct reprogramming; iPSC reprogramming; oligodendrocytes; transdifferentiation; SOMATIC-CELLS; FUNCTIONAL-NEURONS; HUMAN FIBROBLASTS; EFFICIENT GENERATION; MOUSE FIBROBLASTS; IPS CELLS; IN-VITRO; INDUCTION; GENES; CARDIOMYOCYTES;

D O I：

10.2217/rme.16.5

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Rapid progress in the field of stem cell therapy and cellular reprogramming provides convincing evidence of its feasibility in treating a wide range of pathologies through autologous cell replacement therapy. This review article describes in detail on three widely used approaches of somatic cell reprogramming: induced pluripotent stem cells, direct conversion and direct reprogramming, in the context of demyelination in the CNS. The potential limitations of each reprogramming technique are reviewed along with their distinct molecular approach to reprogramming. This is followed by an analysis on the scopes and challenges of its translational applications in deriving oligodendrocyte progenitor cells and oligodendrocytes for cell replacement treatment of demyelinating conditions in the CNS.

引用

页码：181 / 191

页数：11

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