C-H and N-H Bond Annulation of Benzamides with Isonitriles Catalyzed by Cobalt(III)

被引：29

作者：

Kalsi, Deepti ^{[1
]}

Barsu, Nagaraju ^{[1
]}

Dahiya, Pardeep ^{[1
]}

Sundararaju, Basker ^{[1
]}

机构：

[1] Indian Inst Technol Kanpur, Dept Chem, Fine Chem Lab, Kanpur, Uttar Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2017年 / 49卷 / 17期

关键词：

cobalt; annulation; isonitrile; C-H activation; iminoisoindolinone; ISOCYANIDE INSERTION; DIRECTING GROUP; ACTIVATION; FUNCTIONALIZATION; DERIVATIVES; ALKYNES; AMIDES; NICKEL; ALLYLATION; ACCESS;

D O I：

10.1055/s-0036-1589011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple efficient, atom-economical procedure was developed for the cobalt-catalyzed C-H bond annulation of benzamides with isonitriles under mild conditions. The reaction tolerates a variety of functional group including heterocycles. Diverse 3-(alkylimino)-2-quinolin-8-yl-2,3-dihydro-1H-isoindol-1-ones were synthesized using isonitriles as the C1 source through C-H and N-H bond annulation via C-H bond activation in a 'green' solvent. Vinylamides were also used similarly with tert-butyl isonitrile to give 3-(tert-butylimino)-1-quinolin-8-yl-1H-pyrrol-2(5H)-ones.

引用

页码：3937 / 3944

页数：8

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