C-H and N-H Bond Annulation of Benzamides with Isonitriles Catalyzed by Cobalt(III)

被引：29
作者：
Kalsi, Deepti [1 ]
Barsu, Nagaraju [1 ]
Dahiya, Pardeep [1 ]
Sundararaju, Basker [1 ]
机构：
[1] Indian Inst Technol Kanpur, Dept Chem, Fine Chem Lab, Kanpur, Uttar Pradesh, India
来源：
SYNTHESIS-STUTTGART | 2017年 / 49卷 / 17期
关键词：
cobalt; annulation; isonitrile; C-H activation; iminoisoindolinone; ISOCYANIDE INSERTION; DIRECTING GROUP; ACTIVATION; FUNCTIONALIZATION; DERIVATIVES; ALKYNES; AMIDES; NICKEL; ALLYLATION; ACCESS;
D O I：
10.1055/s-0036-1589011
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple efficient, atom-economical procedure was developed for the cobalt-catalyzed C-H bond annulation of benzamides with isonitriles under mild conditions. The reaction tolerates a variety of functional group including heterocycles. Diverse 3-(alkylimino)-2-quinolin-8-yl-2,3-dihydro-1H-isoindol-1-ones were synthesized using isonitriles as the C1 source through C-H and N-H bond annulation via C-H bond activation in a 'green' solvent. Vinylamides were also used similarly with tert-butyl isonitrile to give 3-(tert-butylimino)-1-quinolin-8-yl-1H-pyrrol-2(5H)-ones.
引用
收藏
页码：3937 / 3944
页数：8
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