The Role of Finerenone in the Management of Diabetic Nephropathy

被引：14
作者：
Veneti, Stavroula [1 ]
Tziomalos, Konstantinos [1 ]
机构：
[1] Aristotle Univ Thessaloniki, Propedeut Dept Internal Med 1, Med Sch, AHEPA Hosp, 1 Stilponos Kyriakidi St, Thessaloniki 54636, Greece
来源：
DIABETES THERAPY | 2021年 / 12卷 / 07期
关键词：
Albuminuria; Diabetic kidney disease; Diabetic nephropathy; Finerenone; Mineralocorticoid receptor antagonists; Type 2 diabetes mellitus; CHRONIC KIDNEY-DISEASE; RECEPTOR ANTAGONIST FINERENONE; CHRONIC HEART-FAILURE; BAY; 94-8862; PHARMACOKINETICS; MECHANISMS; TOLERABILITY; ALBUMINURIA; METABOLISM; MELLITUS;
D O I：
10.1007/s13300-021-01085-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetic nephropathy (DN) is the leading cause of chronic kidney disease. Even though mineralocorticoid receptor antagonists (MRA) induce incremental reductions in urine albumin excretion when added to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, this combination is infrequently used because of an increased risk of hyperkalemia. In this context, finerenone, a novel selective MRA that appears to be associated with lower risk for hyperkalemia compared with other MRAs (spironolactone and eplerenone), might represent a useful tool in patients with DN. A recent large randomized trial suggested that finerenone delays the progression of DN and might also reduce cardiovascular morbidity in patients with DN. However, more data are needed to clarify the safety and efficacy of finerenone in this high-risk population.
引用
收藏
页码：1791 / 1797
页数：7
相关论文
共 36 条
  • [1] Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine
    Agarwal, Rajiv
    Kolkhof, Peter
    Bakris, George
    Bauersachs, Johann
    Haller, Hermann
    Wada, Takashi
    Zannad, Faiez
    [J]. EUROPEAN HEART JOURNAL, 2021, 42 (02) : 152 - 161
  • [2] Diabetic Kidney Disease Challenges, Progress, and Possibilities
    Alicic, Radica Z.
    Rooney, Michele T.
    Tuttle, Katherine R.
    [J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2017, 12 (12): : 2032 - 2045
  • [3] 11. Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes-2021
    不详
    [J]. DIABETES CARE, 2021, 44 : S151 - S167
  • [4] Molecular mechanisms in the pathogenesis of diabetic nephropathy: An update
    Arora, Mandeep Kumar
    Singh, Umesh Kumar
    [J]. VASCULAR PHARMACOLOGY, 2013, 58 (04) : 259 - 271
  • [5] Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes
    Bakris, George L.
    Agarwal, Rajiv
    Anker, Stefan D.
    Pitt, Bertram
    Ruilope, Luis M.
    Rossing, Peter
    Kolkhof, Peter
    Nowack, Christina
    Schloemer, Patrick
    Joseph, Amer
    Filippatos, Gerasimos
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (23) : 2219 - 2229
  • [6] Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy A Randomized Clinical Trial
    Bakris, George L.
    Agarwal, Rajiv
    Chan, Juliana C.
    Cooper, Mark E.
    Gansevoort, Ron T.
    Haller, Hermann
    Remuzzi, Giuseppe
    Rossing, Peter
    Schmieder, Roland E.
    Nowack, Christina
    Kolkhof, Peter
    Joseph, Amer
    Pieper, Alexander
    Kimmeskamp-Kirschbaum, Nina
    Ruilope, Luis M.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2015, 314 (09): : 884 - 894
  • [7] Pathophysiologic mechanisms in diabetic kidney disease: A focus on current and future therapeutic targets
    Barrera-Chimal, Jonatan
    Jaisser, Frederic
    [J]. DIABETES OBESITY & METABOLISM, 2020, 22 : 16 - 31
  • [8] The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling
    Barrera-Chimal, Jonatan
    Estrela, Gabriel R.
    Lechner, Sebastian M.
    Giraud, Sebastien
    El Moghrabi, Soumaya
    Kaaki, Shiem
    Kolkhof, Peter
    Hauet, Thierry
    Jaisser, Frederic
    [J]. KIDNEY INTERNATIONAL, 2018, 93 (06) : 1344 - 1355
  • [9] Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1
    Barrera-Chimal, Jonatan
    Andre-Gregoire, Gwennan
    Cat, Aurelie Nguyen Dinh
    Lechner, Sebastian M.
    Cau, Jerome
    Prince, Sonia
    Kolkhof, Peter
    Loirand, Gervaise
    Sauzeau, Vincent
    Hauet, Thierry
    Jaisser, Frederic
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2017, 28 (04): : 1216 - 1226
  • [10] Mineralocorticoid receptor antagonism improves diastolic dysfunction in chronic kidney disease in mice
    Bonnard, Benjamin
    Pieronne-Deperrois, Marie
    Djerada, Zoubir
    Elmoghrabi, Soumaya
    Kolkhof, Peter
    Ouvrard-Pascaud, Antoine
    Mulder, Paul
    Jaisser, Frederic
    Messaoudi, Smail
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2018, 121 : 124 - 133
1234