The chemical mechanisms of the enzymes in the branched-chain amino acids biosynthetic pathway and their applications

被引：20
作者：
Liang, Yan-Fei [1 ]
Long, Zi-Xian [1 ]
Zhang, Ya-Jian [1 ]
Luo, Cai-Yun [1 ]
Yan, Le-Tian [1 ]
Gao, Wen-Yun [1 ]
Li, Heng [1 ]
机构：
[1] Northwest Univ, Coll Life Sci, Natl Engn Res Ctr Miniaturized Detect Syst, Xian 710069, Peoples R China
来源：
BIOCHIMIE | 2021年 / 184卷
基金：
中国国家自然科学基金;
关键词：
Branched-chain amino acids; Biosynthesis; Enzymes; Mechanism; Applications; ALPHA-ISOPROPYLMALATE SYNTHASE; BACTERIAL ACETOHYDROXYACID SYNTHASE; REACTION-INTERMEDIATE ANALOGS; GENETIC FINE-STRUCTURE; BIS-MANNICH BASES; ESCHERICHIA-COLI; MYCOBACTERIUM-TUBERCULOSIS; CRYSTAL-STRUCTURE; 3-ISOPROPYLMALATE DEHYDROGENASE; SALMONELLA-TYPHIMURIUM;
D O I：
10.1016/j.biochi.2021.02.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
L-Valine, L-isoleucine, and L-leucine are three key proteinogenic amino acids, and they are also the essential amino acids required for mammalian growth, possessing important and to some extent, special physiological and biological functions. Because of the branched structures in their carbon chains, they are also named as branched-chain amino acids (BCAAs). This review will highlight the advance in studies of the enzymes involved in the biosynthetic pathway of BCAAs, concentrating on their chemical mechanisms and applications in screening herbicides and antibacterial agents. The uses of some of these enzymes in lab scale organic synthesis are also discussed. (C) 2021 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
引用
收藏
页码：72 / 87
页数：16
相关论文
共 178 条
  • [1] InKluyveromyces lactisa Pair of Paralogous Isozymes Catalyze the First Committed Step of Leucine Biosynthesis in Either the Mitochondria or the Cytosol
    Aguirre-Lopez, Beatriz
    Escalera-Fanjul, Ximena
    Hersch-Gonzalez, Jaqueline
    Rojas-Ortega, Erendira
    El-Hafidi, Mohammed
    Lezama, Mijail
    Gonzalez, James
    Bianchi, Michele Maria
    Lopez, Geovani
    Marquez, Dariel
    Scazzocchio, Claudio
    Riego-Ruiz, Lina
    Gonzalez, Alicia
    [J]. FRONTIERS IN MICROBIOLOGY, 2020, 11
  • [2] A Lysine-Tyrosine Pair Carries Out Acid-Base Chemistry in the Metal Ion-Dependent Pyridine Dinucleotide-Linked β-Hydroxyacid Oxidative Decarboxylases
    Aktas, Deniz F.
    Cook, Paul F.
    [J]. BIOCHEMISTRY, 2009, 48 (16) : 3565 - 3577
  • [3] Determination and stereochemistry of proteinogenic and non-proteinogenic amino acids in Saudi Arabian date fruits
    Ali, Hatem Salama Mohamed
    Alhaj, Omar Amin
    Al-Khalifa, Abdulrahman Saleh
    Brueckner, Hans
    [J]. AMINO ACIDS, 2014, 46 (09) : 2241 - 2257
  • [4] ARFIN SM, 1969, J BIOL CHEM, V244, P1118
  • [5] ARFIN SM, 1969, J BIOL CHEM, V244, P2250
  • [6] ARMSTRONG F, 1961, J BIOL CHEM, V236, P2027
  • [7] STEREOSELECTIVITY AND STEREOSPECIFICITY OF ALPHA,BETA-DIHYDROXY ACID DEHYDRATASE FROM SALMONELLA-TYPHIMURIUM
    ARMSTRONG, FB
    MULLER, US
    REARY, JB
    WHITEHOUSE, D
    CROUT, DHG
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 498 (02) : 282 - 293
  • [8] Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels
    Atsumi, Shota
    Hanai, Taizo
    Liao, James C.
    [J]. NATURE, 2008, 451 (7174) : 86 - U13
  • [9] OXALYL HYDROXAMATES AS REACTION-INTERMEDIATE ANALOGS FOR KETOL-ACID REDUCTOISOMERASE
    AULABAUGH, A
    SCHLOSS, JV
    [J]. BIOCHEMISTRY, 1990, 29 (11) : 2824 - 2830
  • [10] The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster
    Bashiri, Ghader
    Grove, Tyler L.
    Hegde, Subray S.
    Lagautriere, Thomas
    Gerfen, Gary J.
    Almo, Steven C.
    Squire, Christopher J.
    Blanchard, John S.
    Baker, Edward N.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 294 (35) : 13158 - 13170
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