Galanthamine biosynthesis in plant in vitro systems

被引：29

作者：

Berkov, Strahil ^{[1
]}

Ivanov, Ivan ^{[2
]}

Georgiev, Vasil ^{[3
,4
]}

Codina, Carles ^{[5
]}

Pavlov, Atanas ^{[6
]}

机构：

[1] Inst Biodivers & Ecosyst Res, Sofia 1113, Bulgaria

[2] Univ Food Technol, Dept Organ Chem, Plovdiv, Bulgaria

[3] Bulgarian Acad Sci, Stefan Angeloff Inst Microbiol, Lab Appl Biotechnol, Plovdiv, Bulgaria

[4] Florida A&M Univ, Ctr Viticulture & Small Fruit Res, Tallahassee, FL 32307 USA

[5] Univ Barcelona, Fac Farm, Dept Prod Nat Biol Vegetal & Edafol, E-08028 Barcelona, Spain

[6] Univ Food Technol, Dept Analyt Chem, Plovdiv, Bulgaria

来源：

ENGINEERING IN LIFE SCIENCES | 2014年 / 14卷 / 06期

关键词：

Acetylcholinesterase inhibitor; Bioreactors; Biosynthesis; Galanthamine; Plant in vitro systems; SHOOT-CLUMP CULTURES; LEUCOJUM-AESTIVUM; NARCISSUS-CONFUSUS; SOMATIC EMBRYOGENESIS; ALKALOIDS; BIOREACTOR; ELICITATION; PRECURSOR; SUCROSE; GROWTH;

D O I：

10.1002/elsc.201300159

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The Amaryllidaceae alkaloid galanthamine (Gal) is a long-acting, selective, reversible, and competitive acetylcholinesterase inhibitor used for the treatment of early-to mid-stage Alzheimer's disease, poliomyelitis, and other neurological diseases. Currently, Gal is produced by extraction from plants such as daffodils (Narcissus cultivar Carlthon), snowflake (Leucojum aestivum), "red-tubed lily" (Lycoris radiata), and Ungernia victoria, and alternatively by chemical synthesis. Due to the increased demand by the generic pharmaceutical companies and the limited availability of plant sources, the biosynthesis of Gal by plant in vitro systems has been considered as an alternative approach for its sustainable production. The present article reviews the state of the art of in vitro Gal biosynthesis including growth regulators, medium components, culture conditions, elicitation, and bioreactor systems. It may be used as a starting point for further studies in this area leading to a progress in biotechnological production of this valuable alkaloid.

引用

页码：643 / 650

页数：8

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