Specific targeting of IL-6 signalling pathway: a new way to treat IBD?

被引：18
作者：
Desreumaux, P [1 ]
机构：
[1] CHU Lille, Lab Rech Malad Inflammatoires Intestinales, F-59037 Lille, France
来源：
GUT | 2000年 / 47卷 / 04期
关键词：
D O I：
10.1136/gut.47.4.465
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
引用
收藏
页码：465 / 466
页数：2
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共 12 条
[1]  
ADERKA D, 1989, J IMMUNOL, V143, P3517
[2]   Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation:: Evidence in Crohn disease and experimental colitis in vivo [J].
Atreya, R ;
Mudter, J ;
Finotto, S ;
Müllberg, J ;
Jostock, T ;
Wirtz, S ;
Schütz, M ;
Bartsch, B ;
Holtmann, M ;
Becker, C ;
Strand, D ;
Czaja, J ;
Schlaak, JF ;
Lehr, HA ;
Autschbach, F ;
Schürmann, G ;
Nishimoto, N ;
Yoshizaki, K ;
Ito, H ;
Kishimoto, T ;
Galle, PR ;
Rose-John, S ;
Neurath, MF .
NATURE MEDICINE, 2000, 6 (05) :583-588
[3]   DEFECTIVE INFLAMMATORY RESPONSE IN INTERLEUKIN 6-DEFICIENT MICE [J].
FATTORI, E ;
CAPPELLETTI, M ;
COSTA, P ;
SELLITTO, C ;
CANTONI, L ;
CARELLI, M ;
FAGGIONI, R ;
FANTUZZI, G ;
GHEZZI, P ;
POLI, V .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (04) :1243-1250
[4]   EVIDENCE FOR CONTINUOUS STIMULATION OF INTERLEUKIN-6 PRODUCTION IN CROHNS-DISEASE [J].
GROSS, V ;
ANDUS, T ;
CAESAR, I ;
ROTH, M ;
SCHOLMERICH, J .
GASTROENTEROLOGY, 1992, 102 (02) :514-519
[5]  
Ina K, 1999, J IMMUNOL, V163, P1081
[6]   SOLUBLE INTERLEUKIN-6 RECEPTORS IN INFLAMMATORY BOWEL-DISEASE - RELATION TO CIRCULATING INTERLEUKIN-6 [J].
MITSUYAMA, K ;
TOYONAGA, A ;
SASAKI, E ;
ISHIDA, O ;
IKEDA, H ;
TSURUTA, O ;
HARADA, K ;
TATEISHI, H ;
NISHIYAMA, T ;
TANIKAWA, K .
GUT, 1995, 36 (01) :45-49
[7]   Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3-and SHP2-mediated signals in immune responses [J].
Ohtani, T ;
Ishihara, K ;
Atsumi, T ;
Nishida, K ;
Kaneko, Y ;
Miyata, T ;
Itoh, S ;
Narimatsu, M ;
Maeda, H ;
Fukada, T ;
Itoh, M ;
Okano, H ;
Hibi, M ;
Hirano, T .
IMMUNITY, 2000, 12 (01) :95-105
[8]   Interleukin-6 and soluble interleukin-6 receptor:: Direct stimulation of gp130 and hematopoiesis [J].
Peters, M ;
Müller, AM ;
Rose-John, S .
BLOOD, 1998, 92 (10) :3495-3504
[9]   Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4(+) T cells [J].
Rincon, M ;
Anguita, J ;
Nakamura, T ;
Fikrig, E ;
Flavell, RA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (03) :461-469
[10]   Preliminary evaluation of safety and activity of recombinant human interleukin 11 in patients with active Crohn's disease [J].
Sands, BE ;
Bank, S ;
Sninsky, CA ;
Robinson, M ;
Katz, S ;
Singleton, JW ;
Miner, PB ;
Safdi, MA ;
Galandiuk, S ;
Hanauer, SB ;
Varilek, GW ;
Buchman, AL ;
Rodgers, VD ;
Salzberg, B ;
Cai, B ;
Loewy, J ;
DeBruin, MF ;
Rogge, H ;
Shapiro, M ;
Schwertschlag, US .
GASTROENTEROLOGY, 1999, 117 (01) :58-64
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