The Significance of Liquid Biopsy in Pancreatic Cancer

被引：43
作者：
Qi, Zi-Hao [1 ,2 ,3 ,4 ]
Xu, Hua-Xiang [1 ,2 ,3 ,4 ]
Zhang, Shi-Rong [1 ,2 ,3 ,4 ]
Xu, Jin-Zhi [1 ,2 ,3 ,4 ]
Li, Shuo [1 ,2 ,3 ,4 ]
Gao, He-Li [1 ,2 ,3 ,4 ]
Jin, Wei [1 ,2 ,3 ,4 ]
Wang, Wen-Quan [1 ,2 ,3 ,4 ]
Wu, Chun-Tao [1 ,2 ,3 ,4 ]
Ni, Quan-Xing [1 ,2 ,3 ,4 ]
Yu, Xian-Jun [1 ,2 ,3 ,4 ]
Liu, Liang [1 ,2 ,3 ,4 ]
机构：
[1] Fudan Univ, Dept Pancreat Surg, Shanghai Canc Ctr, 270 Dong An Rd, Shanghai 200032, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China
[3] Shanghai Pancreat Canc Inst, Shanghai 200032, Peoples R China
[4] Fudan Univ, Pancreat Canc Inst, Shanghai 200032, Peoples R China
来源：
JOURNAL OF CANCER | 2018年 / 9卷 / 18期
基金：
美国国家科学基金会;
关键词：
Circulating tumor cells; Cell-free nucleic acid; Exosomes; Liquid biopsy; Pancreatic cancer; CIRCULATING TUMOR-CELLS; NUCLEIC-ACIDS; FREE DNA; DISEASE PROGRESSION; EDUCATED PLATELETS; CLINICAL-RELEVANCE; PAN-CANCER; SERUM DNA; BIOMARKER; EXOSOMES;
D O I：
10.7150/jca.24591
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer. The 5-year survival rate for PDAC remains low because it is always diagnosed at an advanced stage and it is resistant to therapy. A biomarker, which could detect asymptomatic premalignant or early malignant tumors and predict the response to treatment, will benefit patients with PDAC. However, traditional biopsy has its limitations. There is an urgent need for a tumor biomarker that could easily and repeatedly sample and monitor, in real time, the progress of tumor development. Liquid biopsy could be a tool to assess potential biomarkers. In this review, we focused on the latest discoveries and advancements of liquid biopsy technology in pancreatic cancer research and demonstrated how this technology is being used in clinical applications.
引用
收藏
页码：3417 / 3426
页数：10
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