Palladium catalysed tandem cyclisation-anion capture.: Part 6:: Synthesis of sugar, nucleoside, purine, benzodiazepinone and β-lactam analogues via capture of in situ generated vinylstannanes

被引：33

作者：

Casaschi, A ^{[1
]}

Grigg, R ^{[1
]}

Sansano, JM ^{[1
]}

机构：

[1] Univ Leeds, Mol Innovat Divers & Automated Synthesis Ctr, Leeds LS2 9JT, W Yorkshire, England

来源：

TETRAHEDRON | 2000年 / 56卷 / 38期

基金：

英国工程与自然科学研究理事会;

关键词：

cascade reactions; palladium catalysis; hydrostannylation; Stille coupling; cyclisation;

D O I：

10.1016/S0040-4020(00)00661-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The regioselective palladium catalysed hydrostannylation of alkynes bearing a beta-heteroatom affords mainly alpha-vinyltin(IV) compounds that are used as terminating species in palladium catalysed cyclisation-anion capture processes. The pharmacophore attached to the alkyne moiety permits the synthesis of sugars, nucleosides, purines, benzodiazepinones and beta-lactams analogues in good yields. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7553 / 7560

页数：8

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