Palladium catalysed tandem cyclisation-anion capture.: Part 6:: Synthesis of sugar, nucleoside, purine, benzodiazepinone and β-lactam analogues via capture of in situ generated vinylstannanes

被引：33
|
作者：
Casaschi, A [1 ]
Grigg, R [1 ]
Sansano, JM [1 ]
机构：
[1] Univ Leeds, Mol Innovat Divers & Automated Synthesis Ctr, Leeds LS2 9JT, W Yorkshire, England
来源：
TETRAHEDRON | 2000年 / 56卷 / 38期
基金：
英国工程与自然科学研究理事会;
关键词：
cascade reactions; palladium catalysis; hydrostannylation; Stille coupling; cyclisation;
D O I：
10.1016/S0040-4020(00)00661-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The regioselective palladium catalysed hydrostannylation of alkynes bearing a beta-heteroatom affords mainly alpha-vinyltin(IV) compounds that are used as terminating species in palladium catalysed cyclisation-anion capture processes. The pharmacophore attached to the alkyne moiety permits the synthesis of sugars, nucleosides, purines, benzodiazepinones and beta-lactams analogues in good yields. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7553 / 7560
页数：8
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