共 135 条
miRNA in tumour metabolism and why could it be the preferred pathway for energy reprograming
被引:33
作者:

Alamoudi, Aliaa A.
论文数: 0 引用数: 0
h-index: 0
机构:
King Abdulaziz Univ, Dept Clin Biochem, POB 80200, Jeddah 21589, Saudi Arabia King Abdulaziz Univ, Dept Clin Biochem, POB 80200, Jeddah 21589, Saudi Arabia

Alnoury, Amina
论文数: 0 引用数: 0
h-index: 0
机构:
King Abdulaziz Univ, Dept Clin Biochem, POB 80200, Jeddah 21589, Saudi Arabia King Abdulaziz Univ, Dept Clin Biochem, POB 80200, Jeddah 21589, Saudi Arabia

Gad, Hoda
论文数: 0 引用数: 0
h-index: 0
机构:
King Abdulaziz Univ, Dept Clin Biochem, POB 80200, Jeddah 21589, Saudi Arabia King Abdulaziz Univ, Dept Clin Biochem, POB 80200, Jeddah 21589, Saudi Arabia
机构:
[1] King Abdulaziz Univ, Dept Clin Biochem, POB 80200, Jeddah 21589, Saudi Arabia
关键词:
miRNA;
tumour metabolism;
Warburg effect;
AMPK;
exosomes;
stemness;
CANCER STEM-CELLS;
GLUCOSE-TRANSPORTER ISOFORMS;
BREAST-CANCER;
AEROBIC GLYCOLYSIS;
LIPID-METABOLISM;
GLUT1;
EXPRESSION;
MESSENGER-RNAS;
IMMUNE CELLS;
HEXOKINASE;
LUNG-CANCER;
D O I:
10.1093/bfgp/elx023
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
The current literature on the role of microRNA (miRNA) in tumour metabolism is growing, and a number of studies regularly confirm the impact miRNA can have in energy reprograming in tumours. However, there remains to be a lack of understanding of the larger perspective of the role of miRNA in the metabolism story. In the first part of this review, we provide a comprehensive and up-to-date description of the extensive role of miRNAs in tumour metabolism including glucose, lipid and amino acid metabolism. However, in the second part, we aim to provide a description of the multidimensional role miRNA can be playing in tumour metabolism. Of paramount importance is the role miRNA has in responding to metabolic cues and how it can alter cellular state and fate, including cancer stem cells, in response to such cues. In addition, exosomal miRNAs can provide means by which cells can communicate metabolic signals and messages with other cells within the tumour microenvironment, altering therefore the phenotype and functional capacity of these cells. With this expanding area of research better understanding of the role of miRNA in tumour metabolism in a mechanistic approach, and not only describing which miRNAs can effect which genes, can help to exploit the therapeutic implications behind the extensive role of miRNA in tumour metabolism.
引用
收藏
页码:157 / 169
页数:13
相关论文
共 135 条
[51]
A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells
[J].
Jiang, Shuai
;
Zhang, Ling-Fei
;
Zhang, Hong-Wei
;
Hu, Song
;
Lu, Ming-Hua
;
Liang, Sheng
;
Li, Biao
;
Li, Yong
;
Li, Dangsheng
;
Wang, En-Duo
;
Liu, Mo-Fang
.
EMBO JOURNAL,
2012, 31 (08)
:1985-1998

Jiang, Shuai
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai Key Lab Mol Androl, Shanghai 200031, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Ctr RNA Res, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China

Zhang, Ling-Fei
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai Key Lab Mol Androl, Shanghai 200031, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Ctr RNA Res, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China

Zhang, Hong-Wei
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Zhongshan Hosp, Dept Gen Surg, Shanghai 200433, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China

Hu, Song
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai Key Lab Mol Androl, Shanghai 200031, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Ctr RNA Res, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China

Lu, Ming-Hua
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai Key Lab Mol Androl, Shanghai 200031, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Ctr RNA Res, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China

Liang, Sheng
论文数: 0 引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Sch Med, Dept Nucl Med, Shanghai 200030, Peoples R China
Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Micro PET Ctr, Shanghai 200030, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China

Li, Biao
论文数: 0 引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Sch Med, Dept Nucl Med, Shanghai 200030, Peoples R China
Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Micro PET Ctr, Shanghai 200030, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China

Li, Yong
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Louisville, Sch Med, Ctr Genet & Mol Med, Dept Biochem & Mol Biol, Louisville, KY 40292 USA Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China

Li, Dangsheng
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Informat Ctr Life Sci, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China

Wang, En-Duo
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Ctr RNA Res, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China

Liu, Mo-Fang
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai Key Lab Mol Androl, Shanghai 200031, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Ctr RNA Res, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, Shanghai 200031, Peoples R China
[52]
Clinicopathologic significance of GLUT1 expression and its correlation with Apaf-1 in colorectal adenocarcinomas
[J].
Jun, Young Jin
;
Jang, Se Min
;
Han, Hu Lin
;
Lee, Kang Hong
;
Jang, Ki-Seok
;
Paik, Seung Sam
.
WORLD JOURNAL OF GASTROENTEROLOGY,
2011, 17 (14)
:1866-1873

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:

Han, Hu Lin
论文数: 0 引用数: 0
h-index: 0
机构:
Hanyang Univ, Coll Med, Dept Pathol, Seoul 133792, South Korea Hanyang Univ, Coll Med, Dept Pathol, Seoul 133792, South Korea

Lee, Kang Hong
论文数: 0 引用数: 0
h-index: 0
机构:
Hanyang Univ, Coll Med, Dept Surg, Seoul 133792, South Korea Hanyang Univ, Coll Med, Dept Pathol, Seoul 133792, South Korea

Jang, Ki-Seok
论文数: 0 引用数: 0
h-index: 0
机构:
Hanyang Univ, Coll Med, Dept Pathol, Seoul 133792, South Korea Hanyang Univ, Coll Med, Dept Pathol, Seoul 133792, South Korea

论文数: 引用数:
h-index:
机构:
[53]
Influence of tumour micro-environment heterogeneity on therapeutic response
[J].
Junttila, Melissa R.
;
de Sauvage, Frederic J.
.
NATURE,
2013, 501 (7467)
:346-354

Junttila, Melissa R.
论文数: 0 引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA

de Sauvage, Frederic J.
论文数: 0 引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA
[54]
Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells
[J].
Kefas, Benjamin
;
Comeau, Laurey
;
Erdle, Nicholas
;
Montgomery, Emmitt
;
Amos, Samson
;
Purow, Benjamin
.
NEURO-ONCOLOGY,
2010, 12 (11)
:1102-1112

Kefas, Benjamin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Virginia Hlth Syst, Div Neurooncol, Dept Neurol, Old Med Sch, Charlottesville, VA 22908 USA Univ Virginia Hlth Syst, Div Neurooncol, Dept Neurol, Old Med Sch, Charlottesville, VA 22908 USA

Comeau, Laurey
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Virginia Hlth Syst, Div Neurooncol, Dept Neurol, Old Med Sch, Charlottesville, VA 22908 USA Univ Virginia Hlth Syst, Div Neurooncol, Dept Neurol, Old Med Sch, Charlottesville, VA 22908 USA

Erdle, Nicholas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Virginia Hlth Syst, Div Neurooncol, Dept Neurol, Old Med Sch, Charlottesville, VA 22908 USA Univ Virginia Hlth Syst, Div Neurooncol, Dept Neurol, Old Med Sch, Charlottesville, VA 22908 USA

Montgomery, Emmitt
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Virginia Hlth Syst, Div Neurooncol, Dept Neurol, Old Med Sch, Charlottesville, VA 22908 USA Univ Virginia Hlth Syst, Div Neurooncol, Dept Neurol, Old Med Sch, Charlottesville, VA 22908 USA

论文数: 引用数:
h-index:
机构:

Purow, Benjamin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Virginia Hlth Syst, Div Neurooncol, Dept Neurol, Old Med Sch, Charlottesville, VA 22908 USA Univ Virginia Hlth Syst, Div Neurooncol, Dept Neurol, Old Med Sch, Charlottesville, VA 22908 USA
[55]
Hypoxia-inducible factor I and dysregulated c-myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
[J].
Kim, Jung-Whan
;
Gao, Ping
;
Liu, Yen-Chun
;
Semenza, Gregg L.
;
Dang, Chi V.
.
MOLECULAR AND CELLULAR BIOLOGY,
2007, 27 (21)
:7381-7393

Kim, Jung-Whan
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Div Hematol, Baltimore, MD 21205 USA

Gao, Ping
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Div Hematol, Baltimore, MD 21205 USA

Liu, Yen-Chun
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Div Hematol, Baltimore, MD 21205 USA

Semenza, Gregg L.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Div Hematol, Baltimore, MD 21205 USA

Dang, Chi V.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Div Hematol, Baltimore, MD 21205 USA
[56]
CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression
[J].
Kirk, P
;
Wilson, MC
;
Heddle, C
;
Brown, MH
;
Barclay, AN
;
Halestrap, AP
.
EMBO JOURNAL,
2000, 19 (15)
:3896-3904

Kirk, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England

Wilson, MC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England

Heddle, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England

Brown, MH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England

Barclay, AN
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England

Halestrap, AP
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England
[57]
Expression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential
[J].
Knezevic, J.
;
Pfefferle, A. D.
;
Petrovic, I.
;
Greene, S. B.
;
Perou, C. M.
;
Rosen, J. M.
.
ONCOGENE,
2015, 34 (49)
:5997-6006

Knezevic, J.
论文数: 0 引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

Pfefferle, A. D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

Petrovic, I.
论文数: 0 引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

Greene, S. B.
论文数: 0 引用数: 0
h-index: 0
机构:
Epic Sci Inc, San Diego, CA USA Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

Perou, C. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Genet, Chapel Hill, NC USA Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

Rosen, J. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
[58]
Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells
[J].
Koch, Andreas
;
Lang, Sven Arke
;
Wild, Peter Johannes
;
Gantner, Susanne
;
Mahli, Abdo
;
Spanier, Gerrit
;
Berneburg, Mark
;
Mueller, Martina
;
Bosserhoff, Anja Katrin
;
Hellerbrand, Claus
.
ONCOTARGET,
2015, 6 (32)
:32748-32760

Koch, Andreas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany

Lang, Sven Arke
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Regensburg, Dept Surg, Regensburg, Germany Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany

Wild, Peter Johannes
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Zurich Hosp, Inst Pathol, Zurich, Switzerland Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany

Gantner, Susanne
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Regensburg, Dept Dermatol, Regensburg, Germany Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany

Mahli, Abdo
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany

Spanier, Gerrit
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Regensburg, Dept Craniomaxillofacial Surg, Regensburg, Germany Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany

Berneburg, Mark
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Regensburg, Dept Dermatol, Regensburg, Germany Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany

Mueller, Martina
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany

Bosserhoff, Anja Katrin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Erlangen Nurnberg, Inst Biochem, Erlangen, Germany Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany

Hellerbrand, Claus
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany
[59]
Otto Warburg's contributions to current concepts of cancer metabolism
[J].
Koppenol, Willem H.
;
Bounds, Patricia L.
;
Dang, Chi V.
.
NATURE REVIEWS CANCER,
2011, 11 (05)
:325-337

Koppenol, Willem H.
论文数: 0 引用数: 0
h-index: 0
机构:
Swiss Fed Inst Technol, Inst Inorgan Chem, CH-8093 Zurich, Switzerland Swiss Fed Inst Technol, Inst Inorgan Chem, CH-8093 Zurich, Switzerland

Bounds, Patricia L.
论文数: 0 引用数: 0
h-index: 0
机构:
Swiss Fed Inst Technol, Inst Inorgan Chem, CH-8093 Zurich, Switzerland Swiss Fed Inst Technol, Inst Inorgan Chem, CH-8093 Zurich, Switzerland

Dang, Chi V.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21212 USA Swiss Fed Inst Technol, Inst Inorgan Chem, CH-8093 Zurich, Switzerland
[60]
p53 in survival, death and metabolic health: a lifeguard with a licence to kill
[J].
Kruiswijk, Flore
;
Labuschagne, Christiaan F.
;
Vousden, Karen H.
.
NATURE REVIEWS MOLECULAR CELL BIOLOGY,
2015, 16 (07)
:393-405

Kruiswijk, Flore
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK Beatson Inst, Glasgow G61 1BD, Lanark, Scotland Canc Res UK Beatson Inst, Glasgow G61 1BD, Lanark, Scotland

Labuschagne, Christiaan F.
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK Beatson Inst, Glasgow G61 1BD, Lanark, Scotland Canc Res UK Beatson Inst, Glasgow G61 1BD, Lanark, Scotland

Vousden, Karen H.
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK Beatson Inst, Glasgow G61 1BD, Lanark, Scotland Canc Res UK Beatson Inst, Glasgow G61 1BD, Lanark, Scotland