Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors

被引：216

作者：

Dixit, Suraj ^{[1
,2
]}

Novak, Thomas ^{[1
]}

Miller, Kayla ^{[2
]}

Zhu, Yun ^{[1
,2
]}

Kenney, Malcolm E. ^{[3
]}

Broome, Ann-Marie ^{[1
,2
]}

机构：

[1] Med Univ S Carolina, Ctr Biomed Imaging, Charleston, SC 29425 USA

[2] Med Univ S Carolina, Dept Radiol & Radiol Sci, Charleston, SC 29425 USA

[3] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA

来源：

NANOSCALE | 2015年 / 7卷 / 05期

关键词：

IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; MAGNETIC NANOPARTICLES; COLLOIDAL GOLD; GENE DELIVERY; CANCER-CELLS; IN-VIVO; MRI; GLIOMA; PACLITAXEL;

D O I：

10.1039/c4nr04853a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Therapeutic drug delivery across the blood-brain barrier (BBB) is not only inefficient, but also nonspecific to brain stroma. These are major limitations in the effective treatment of brain cancer. Transferrin peptide (Tf-pep) targeted gold nanoparticles (Tf-pep-Au NPs) loaded with the photodynamic pro-drug, Pc 4, have been designed and compared with untargeted Au NPs for delivery of the photosensitizer to brain cancer cell lines. In vitro studies of human glioma cancer lines (LN229 and U87) overexpressing the transferrin receptor (TfR) show a significant increase in cellular uptake for targeted conjugates as compared to untargeted particles. Pc 4 delivered from Tf-pep-Au NPs clusters within vesicles after targeting with the Tf-pep. Pc 4 continues to accumulate over a 4 hour period. Our work suggests that TfR-targeted Au NPs may have important therapeutic implications for delivering brain tumor therapies and/or providing a platform for noninvasive imaging.

引用

页码：1782 / 1790

页数：9

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