Innate immunity of the newborn: basic mechanisms and clinical correlates

被引:904
作者
Levy, Ofer [1 ]
机构
[1] Childrens Hosp Boston, Div Infect Dis, Dept Med, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nri2075
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The fetus and newborn face a complex set of immunological demands, including protection against infection, avoidance of harmful inflammatory immune responses that can lead to pre-term delivery, and balancing the transition from a sterile intra-uterine environment to a world that is rich in foreign antigens. These demands shape a distinct neonatal innate immune system that is biased against the production of pro-inflammatory cytokines. This bias renders newborns at risk of infection and impairs responses to many vaccines. This Review describes innate immunity in newborns and discusses how this knowledge might be used to prevent and treat infection in this vulnerable population.
引用
收藏
页码:379 / 390
页数:12
相关论文
共 166 条
[141]   Genetic susceptibility to neonatal infection [J].
Strunk, Tobias ;
Burgner, David .
CURRENT OPINION IN INFECTIOUS DISEASES, 2006, 19 (03) :259-263
[142]   Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs [J].
Sun, CM ;
Deriaud, E ;
Leclerc, C ;
Lo-Man, R .
IMMUNITY, 2005, 22 (04) :467-477
[143]   Ontogeny and innate properties of neonatal dendritic cells [J].
Sun, CM ;
Fiette, L ;
Tanguy, M ;
Leclerc, C ;
Lo-Man, R .
BLOOD, 2003, 102 (02) :585-591
[144]   Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions [J].
Tollin, M ;
Bergsson, G ;
Kai-Larsen, Y ;
Lengqvist, J ;
Sjövall, J ;
Griffiths, W ;
Skúladóttir, GV ;
Haraldsson, A ;
Jörnvall, H ;
Gudmundsson, GH ;
Agerberth, B .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2005, 62 (19-20) :2390-2399
[145]   Proteome analysis of vernix caseosa [J].
Tollin, Maria ;
Jagerbrink, Theres ;
Haraldsson, Asgeir ;
Agerberth, Birgitta ;
Jornvall, Hans .
PEDIATRIC RESEARCH, 2006, 60 (04) :430-434
[146]   Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adults [J].
Tulic, MK ;
Fiset, PO ;
Manoukian, JJ ;
Frenkiel, S ;
Lavigne, F ;
Eidelman, DH ;
Hamid, Q .
LANCET, 2004, 363 (9422) :1689-1697
[147]  
Urlichs F, 2004, NEOREVIEWS, V5, pe417, DOI [DOI 10.1542/NEO.5-10-E417, DOI 10.1542/NE0.5-10-E417]
[148]   Differential cytokine production and toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae [J].
van der Graaf, CAA ;
Netea, MG ;
Verschueren, I ;
van der Meer, JWM ;
Kullberg, BJ .
INFECTION AND IMMUNITY, 2005, 73 (11) :7458-7464
[149]  
van Strien RT, 2004, J ALLERGY CLIN IMMUN, V113, P860, DOI [10.1016/j.jaci.2004.01.783, 10.1016/j.jaci.2004.01.078]
[150]   Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns [J].
Vanden Eijnden, S ;
Goriely, S ;
De Wit, D ;
Goldman, M ;
Willems, F .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2006, 36 (01) :21-26