Microglia Biology: One Century of Evolving Concepts

被引：1026

作者：

Prinz, Marco ^{[1
,2
,3
,4
]}

Jung, Steffen ^{[5
]}

Priller, Josef ^{[6
,7
,8
,9
,10
]}

机构：

[1] Univ Freiburg, Inst Neuropathol, Fac Med, Freiburg, Germany

[2] Univ Freiburg, Signalling Res Ctr BIOSS, Freiburg, Germany

[3] Univ Freiburg, Signalling Res Ctr CIBSS, Freiburg, Germany

[4] Univ Freiburg, Ctr Basics NeuroModulat NeuroModulBasics, Fac Med, Freiburg, Germany

[5] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

[6] Charite Univ Med Berlin, Dept Neuropsychiat & Lab Mol Psychiat, Berlin, Germany

[7] DZNE, Berlin, Germany

[8] BIH, Berlin, Germany

[9] Univ Edinburgh, Edinburgh, Midlothian, Scotland

[10] UK DRI, Edinburgh, Midlothian, Scotland

来源：

CELL | 2019年 / 179卷 / 02期

基金：

欧洲研究理事会;

关键词：

CENTRAL-NERVOUS-SYSTEM; FRACTALKINE RECEPTOR; ALZHEIMERS-DISEASE; RESIDENT MICROGLIA; LANGERHANS CELLS; MYELOID CELLS; YOLK-SAC; MOUSE; MACROPHAGES; BRAIN;

D O I：

10.1016/j.cell.2019.08.053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microglia were first recognized as a distinct cell population in the CNS one century ago. For a long time, they were primarily considered to be phagocytes responsible for removing debris during CNS development and disease. More recently, advances in imaging and genetics and the advent of single-cell technology provided new insights into the much more complex and fascinatir; biology of microglia. The ontogeny of microglia was identified, and their functions in health and disease were better defined. Although many qL lions about microglia and their roles in human diseases remain unanswered, the prospect of targeting microglia for the treatment of neurological and psychiatric disorders is tantalizing.

引用

页码：292 / 311

页数：20

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