The Yin and Yang of Targeting KLRG1+ Tregs and Effector Cells

被引:18
作者
Borys, Samantha M. [1 ]
Bag, Arup K. [2 ]
Brossay, Laurent [1 ]
Adeegbe, Dennis O. [2 ]
机构
[1] Brown Univ Alpert Med Sch, Dept Mol Microbiol & Immunol, Div Biol & Med, Providence, RI USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Immunol, Tampa, FL USA
来源
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
关键词
regulatory T cells (T reg); cancer; KLRG1; immune modulation; Treg targeting; REGULATORY T-CELLS; FUNCTION-ASSOCIATED ANTIGEN; E-CADHERIN; RECEPTOR KLRG1; CUTTING EDGE; EPITHELIAL-CELLS; IL-2; RECEPTOR; EXPRESSION; NK; DIFFERENTIATION;
D O I
10.3389/fimmu.2022.894508
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The literature surrounding KLRG1 has primarily focused on NK and CD8(+) T cells. However, there is evidence that the most suppressive Tregs express KLRG1. Until now, the role of KLRG1 on Tregs has been mostly overlooked and remains to be elucidated. Here we review the current literature on KLRG1 with an emphasis on the KLRG1(+) Treg subset role during cancer development and autoimmunity. KLRG1 has been recently proposed as a new checkpoint inhibitor target, but these studies focused on the effects of KLRG1 blockade on effector cells. We propose that when designing anti-tumor therapies targeting KLRG1, the effects on both effector cells and Tregs will have to be considered.
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页数:8
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共 110 条
  • [31] The NK receptor KLRG1 is dispensable for virus-induced NK and CD8+ T-cell differentiation and function in vivo
    Gruendemann, Carsten
    Schwartzkopff, Sabrina
    Koschella, Marie
    Schweier, Oliver
    Peters, Christoph
    Voehringer, David
    Pircher, Hanspeter
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (05) : 1303 - 1314
  • [32] Cutting edge:: Identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1
    Gründemann, C
    Bauer, M
    Schweier, O
    von Oppen, N
    Lässing, U
    Saudan, P
    Becker, KF
    Karp, K
    Hanke, T
    Bachmann, MF
    Pircher, H
    [J]. JOURNAL OF IMMUNOLOGY, 2006, 176 (03) : 1311 - 1315
  • [33] Regulation of cadherin-mediated adhesion in morphogenesis
    Gumbiner, BM
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (08) : 622 - 634
  • [34] A NEW MEMBER OF THE C-TYPE LECTIN FAMILY IS A MODULATOR OF THE MAST-CELL SECRETORY RESPONSE
    GUTHMANN, MD
    TAL, M
    PECHT, I
    [J]. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1995, 107 (1-3) : 82 - 86
  • [35] Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody
    Ha, Danbee
    Tanaka, Atsushi
    Kibayashi, Tatsuya
    Tanemura, Atsushi
    Sugiyama, Daisuke
    Wing, James Badger
    Lim, Ee Lyn
    Teng, Karen Wei Weng
    Adeegbe, Dennis
    Newell, Evan W.
    Katayama, Ichiro
    Nishikawa, Hiroyoshi
    Sakaguchi, Shimon
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (02) : 609 - 618
  • [36] Back to the thymus: peripheral T cells come home
    Hale, J. Scott
    Fink, Pamela J.
    [J]. IMMUNOLOGY AND CELL BIOLOGY, 2009, 87 (01) : 58 - 64
  • [37] E-protein regulatory network links TCR signaling to effector Treg cell differentiation
    Han, Xiaojuan
    Huang, Huarong
    Gao, Ping
    Zhang, Qi
    Liu, Xinyuan
    Jia, Baoqian
    Strober, Warren
    Hou, Baidong
    Zhou, Xuyu
    Gao, George Fu
    Zhang, Fuping
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (10) : 4471 - 4480
  • [38] Hallmarks of Cancer: The Next Generation
    Hanahan, Douglas
    Weinberg, Robert A.
    [J]. CELL, 2011, 144 (05) : 646 - 674
  • [39] Hanke T, 1998, EUR J IMMUNOL, V28, P4409, DOI 10.1002/(SICI)1521-4141(199812)28:12<4409::AID-IMMU4409>3.0.CO
  • [40] 2-3