Partial Volume Correction on ASL-MRI and Its Application on Alzheimer's Disease Diagnosis

Arterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) method that can provide direct and quantitative measurements of cerebral blood flow (CBF) of scanned patients. ASL can be utilized as an imaging modality to detect Alzheimer's disease (AD), as brain atrophy of AD patients can be revealed by low CBF values in certain brain regions. However, partial volume effects (PVE), which is mainly caused by signal cross-contamination due to voxel heterogeneity and limited spatial resolution of ASL images, often prevents CBF in ASL from being precisely measured. In this study, a novel PVE correction method is proposed based on pixel-wise voxels in ASL images; it can well handle with the existing problems of blurring and loss of brain details in conventional PVE correction methods. Dozens of comparison experiments and statistical analysis also suggest that the proposed method is superior to other PVE correction methods in AD diagnosis based on real patients data.