Potential role of IL-37 signaling pathway in feedback regulation of autoimmune Hashimoto thyroiditis

被引:5
作者
Ren, Cui-Ping [1 ]
Sun, Li [2 ]
Liu, Feng-Chun [1 ]
Zuo, Chun-Lin [2 ]
Liu, Miao [1 ]
Gao, Wenda [3 ]
Shen, Ji-Jia [1 ]
机构
[1] Anhui Med Univ, Dept Microbiol & Parasitol, Sch Basic Med Sci,Anhui Prov Lab Pathogen Biol, Anhui Prov Lab Zoonoses,Lab Trop & Parasit Dis Co, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China
[2] Anhui Med Univ, Dept Endocrinol, Affiliated Hosp 1, 210 JiXi Rd, Hefei 230032, Anhui, Peoples R China
[3] Antagen Inst Biomed Res, Boston, MA 02118 USA
基金
美国国家科学基金会; 中国国家自然科学基金;
关键词
Hashimoto's thyroiditis; Chronic lymphocytic thyroiditis; IL-37; SIGIRR; INTERLEUKIN-37; IL-18R-ALPHA; EXPRESSION; REQUIRES; DISEASE; SIGIRR;
D O I
10.1007/s00418-019-01820-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
IL-37, the anti-inflammatory cytokine of the IL-1 family, plays several key roles in the regulation of autoimmune diseases. Yet, its role in Hashimoto's thyroiditis (HT) is not clear. In the present study, we found that, in tissues from HT patients, most of the follicular epithelial cells were positive for both IL-37 and single Ig IL-1-related receptor (SIGIRR) by immunohistochemical staining, while the infiltrating lymphocytes and other inflammatory cells hardly expressed any. Meanwhile, mRNA expression levels of IL-37 in peripheral blood mononuclear cells (PBMC) of HT patients were significantly higher than those in normal controls measured by quantitative real-time PCR. Finally, we studied the possible role of IL-37 in IFN-gamma-stimulated rat FRTL-5 cells. The results showed that IL-1 beta, TNF-alpha, and MCP-1 mRNA levels were significantly decreased, while the expression of IL-4 mRNA was dramatically up-regulated in IFN-gamma-stimulated rat thyroid cell line FRTL-5 pre-treated with IL-37. The current study, for the first time, demonstrated that the IL-37 network is involved in Hashimoto's thyroiditis, and IL-37 signaling pathway may ameliorate the excessive autoimmune responses in this chronic lymphocytic thyroiditis.
引用
收藏
页码:467 / 473
页数:7
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