Intensive chemotherapy followed by autologous stem cell transplantation in primary central nervous system lymphomas (PCNSLs). Therapeutic outcomes in real life-experience of the French Network

被引：16

作者：

Schenone, Laurence ^{[1
]}

Houillier, Caroline ^{[2
]}

Tanguy, Marie Laure ^{[3
]}

Choquet, Sylvain ^{[4
]}

Agbetiafa, Kossi ^{[5
]}

Ghesquieres, Herve ^{[6
]}

Damaj, Gandhi ^{[7
]}

Schmitt, Anna ^{[8
]}

Bouabdallah, Krimo ^{[9
]}

Ahle, Guido ^{[10
]}

Gressin, Remy ^{[11
]}

Cornillon, Jerome ^{[12
]}

Houot, Roch ^{[13
]}

Marolleau, Jean-Pierre ^{[14
]}

Fornecker, Luc-Matthieu ^{[15
]}

Chinot, Olivier ^{[16
]}

Peyrade, Frederic ^{[17
]}

Bouabdallah, Reda ^{[18
]}

Molucon-Chabrot, Cecile ^{[19
]}

Gyan, Emmanuel ^{[20
]}

Chauchet, Adrien ^{[21
]}

Casasnovas, Olivier ^{[22
]}

Oberic, Lucie ^{[23
]}

Delwail, Vincent ^{[24
]}

Abraham, Julie ^{[25
]}

Roland, Virginie ^{[26
]}

Waultier-Rascalou, Agathe ^{[27
]}

Willems, Lise ^{[28
]}

Morschhauser, Franck ^{[29
]}

Fabbro, Michel ^{[30
]}

Ursu, Renata ^{[31
]}

Thieblemont, Catherine ^{[32
]}

Jardin, Fabrice ^{[33
]}

Tempescul, Adrian ^{[34
]}

Malaise, Denis ^{[35
,36
]}

Touitou, Valerie ^{[37
]}

Nichelli, Lucia ^{[38
]}

Le Garff-Tavernier, Magali ^{[39
]}

Plessier, Aurelie ^{[40
]}

Bourget, Philippe ^{[41
]}

Bonmati, Caroline ^{[42
]}

Wantz-Mezieres, Sophie ^{[43
]}

Giordan, Quentin ^{[44
]}

Dorvaux, Veronique ^{[45
]}

Charron, Cyril ^{[46
]}

Jabeur, Waliyde ^{[47
]}

Hoang-Xuan, Khe ^{[2
]}

Taillandier, Luc ^{[48
]}

Soussain, Carole ^{[5
,49
]}

机构：

[1] Univ Lorraine, Dept Hematol, Hop Brabois, CHRU Nancy, Nancy, France

[2] Sorbonne Univ, Grp Hosp Pitie Salpetriere, AP HP, ICM,IHU,Dept Neurol, Paris, France

[3] Inst Gustave Roussy, Dept Biostat, Paris, France

[4] Sorbonne Univ, Dept Hematol, Hop Pitie Salpetriere, AP HP, Paris, France

[5] Inst Curie, Dept Hematol, Site St Cloud, St Cloud, France

[6] Ctr Hosp Lyon Sud, Dept Hematol, Lyon, France

[7] CHU Caen Normandie, Dept Hematol, Caen, France

[8] Inst Bergonie, Dept Hematol, Bordeaux, France

[9] Univ Hosp Bordeaux, Dept Hematol & Cell Therapy, F-33000 Bordeaux, France

[10] Hop Civils Colmar, Dept Neurol Pole NNORR, Colmar, France

[11] CHU Grenoble, Dept Hematol, Grenoble, France

[12] Inst Cancerol Lucien Neuwirth, Dept Hematol, St Priest En Jarez, France

[13] CHU Rennes, Dept Hematol, Rennes, France

[14] CHU Amiens, Dept Hematol, Amiens, France

[15] Inst Cancerol Strasbourg Europe, Dept Hematol, Strasbourg, France

[16] CHU Timone, AP HM, Dept Neurooncol, Marseille, France

[17] Ctr Antoine Lacassagne, Dept Hematol, Nice, France

[18] Hop Prive Provence, Pole Cancerol, Aix En Provence, France

[19] CHU Clermont Ferrand, Dept Hematol, Clermont Ferrand, France

[20] CHU Tours, Dept Hematol & Cellular Therapy, Tours, France

[21] CHRU Besancon, Dept Hematol, Besancon, France

[22] CHU Dijon Bourgogne, Dept Hematol, Dijon, France

[23] Inst Univ Canc Toulouse, Dept Hematol, Toulouse, France

[24] CHU Poitiers, Dept Hematol & Cellular Therapy, Poitiers, France

[25] CHU Dupuytren Limoges, Dept Hematol, Limoges, France

[26] CH St Jean, Dept Hematol, Perpignan, France

[27] CHU Nimes Caremeau, Dept Hematol, Nimes, France

[28] CHU Paris Ctr, Dept Hematol, Site Cochin, Paris, France

[29] CHRU Lille, Inst Hematol Transfus, Lille, France

[30] Inst Reg Canc Montpellier, Dept Oncol, Montpellier, France

[31] Hop St Louis, AP HP, Dept Neurol, Paris, France

[32] Hop St Louis, AP HP, Dept Hematol, Paris, France

[33] Ctr Henri Becquerel, Dept Hematol, Rouen, France

[34] CHRU Brest, Dept Hematol, Brest, France

[35] Inst Curie, Dept Ophthalmol, Paris, France

[36] PSL Univ, Inst Curie, Lab Imagerie Translat Oncol, Inserm U1288, Orsay, France

[37] Hop La Pitie Salpetriere, AP HP, Dept Ophthalmol, Paris, France

[38] Hop La Pitie Salpetriere, AP HP, Dept Neuroradiol, Paris, France

[39] Hop La Pitie Salpetriere, AP HP, Dept Biol Hematol, Paris, France

[40] Hop Beaujon, AP HP, Dept Hepatogastroenterol, Paris, France

[41] Hop Necker Enfants Malad, AP HP, Dept Funct Explorat, Paris, France

[42] CHRU Nancy, Hop Brabois, Dept Hematol, Nancy, France

[43] Univ Lorraine, IECL, INRIA, CNRS, F-54000 Nancy, France

[44] CHR Metz Thionville, Hop Mercy, Pharm Dept, Metz, France

[45] CHR Metz Thionville, Hop Mercy, Dept Hematol, Metz, France

[46] Univ Hosp Ambroise Pare, AP HP, Intens Care Dept, Boulogne, France

[47] Hop Foch, Dept Neurol, Suresnes, France

[48] CHRU Nancy, Hop Cent, Dept Neurol, Nancy, France

[49] PSL Res Univ, Inst Curie, INSERM U932, Paris, France

来源：

BONE MARROW TRANSPLANTATION | 2022年 / 57卷 / 06期

关键词：

PRIMARY CNS LYMPHOMA; HIGH-DOSE CHEMOTHERAPY; WHOLE-BRAIN RADIOTHERAPY; MARROW-TRANSPLANTATION; INTRAOCULAR LYMPHOMA; POSITION STATEMENT; ELDERLY-PATIENTS; THIOTEPA; CYCLOPHOSPHAMIDE; CONSOLIDATION;

D O I：

10.1038/s41409-022-01648-z

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We analysed the therapeutic outcomes of all consecutive patients with primary central nervous system lymphoma (PCNSL) registered in the prospective French database for PCNSL and treated with intensive chemotherapy (IC) followed by autologous stem cell transplantation (IC-ASCT) between 2011 and November 2019 (271 patients recruited, 266 analysed). In addition, treatment-related complications of thiotepa-based IC-ASCT were analysed from the source files of 85 patients from 3 centers. Patients had received IC-ASCT either in first-line treatment (n = 147) or at relapse (n = 119). The median age at IC-ASCT was 57 years (range: 22-74). IC consisted of thiotepa-BCNU (n = 64), thiotepa-busulfan (n = 24), BCNU-etoposide-cytarabine-melphalan (BEAM, n = 36) and thiotepa-busulfan-cyclophosphamide (n = 142). In multivariate analysis, BEAM and ASCT beyond the first relapse were adverse prognostic factors for relapse risk. The risk of treatment-related mortality was higher for ASCT performed beyond the first relapse and seemed higher for thiotepa-busulfan-cyclophosphamide. Thiotepa-BCNU tends to result in a higher relapse rate than thiotepa-busulfan-cyclophosphamide and thiotepa-busulfan. This study confirms the role of IC-ASCT in first-line treatment and at first-relapse PCNSL (5-year overall survival rates of 80 and 50%, respectively). The benefit/risk ratio of thiotepa-busulfan/thiotepa-busulfan-cyclophosphamide-ASCT could be improved by considering ASCT earlier in the course of the disease and dose adjustment of the IC.

引用

页码：966 / 974

页数：9

共 38 条

[21] Radiotherapy or Autologous Stem-Cell Transplantation for Primary CNS Lymphoma in Patients 60 Years of Age and Younger: Results o the Intergroup ANOCEF-GOELAMS Randomized Phase II PRECIS Study
Houillier, Caroline
Taillandier, Luc
Dureau, Sylvain
Lamy, Thierry
Laadhari, Mouna
Chinot, Olivier
Molucon-Chabrot, Cecile
Soubeyran, Pierre
Gressin, Remy
Choquet, Sylvain
Damaj, Gandhi
Thyss, Antoine
Abraham, Julie
Delwail, Vincent
Gyan, Emmanuel
Sanhes, Laurence
Cornillon, Jerome
Garidi, Reda
Delmer, Alain
Tanguy, Marie-Laure
Al Jijakli, Ahmad
Morel, Pierre
Bourquard, Pascal
Moles, Marie-Pierre
Chauchet, Adrien
Gastinne, Thomas
Constans, Jean-Marc
Langer, Adriana
Martin, Antoine
Moisson, Patricia
Lacomblez, Lucette
Martin-Duverneuil, Nadine
Delgadillo, Daniel
Turbiez, Isabelle
Feuvret, Loic
Cassoux, Nathalie
Touitou, Valerie
Ricard, Damien
Hoang-Xuan, Khe
Soussain, Carole
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (10) : 823 - +
[22] High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial
Illerhaus, Gerald
Kasenda, Benjamin
Ihorst, Gabriele
Egerer, Gerlinde
Lamprecht, Monika
Keller, Ulrich
Wolf, Hans-Heinrich
Hirt, Carsten
Stilgenbauer, Stephan
Binder, Mascha
Hau, Peter
Edinger, Matthias
Frickhofen, Norbert
Bentz, Martin
Moehle, Robert
Roeth, Alexander
Pfreundschuh, Michael
von Baumgarten, Louisa
Deckert, Martina
Hader, Claudia
Fricker, Heidi
Valk, Elke
Schorb, Elisabeth
Fritsch, Kristina
Finke, Juergen
[J]. Lancet Haematology, 2016, 3 (08): : E388 - E397
[23] Outcomes of Autologous Stem Cell Transplant Consolidation in Primary Central Nervous System Lymphoma: A Mayo Clinic Experience
Khurana, Arushi
Micallef, Ivana N.
LaPlant, Betsy R.
O'Neill, Brian Patrick
Habermann, Thomas M.
Ansell, Stephen M.
Inwards, David J.
Porrata, Luis F.
Paludo, Jonas
Bisneto, J. C. Villasboas
Johnston, Patrick B.
[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2020, 26 (12) : 2217 - 2222
[24] Consolidation Therapy in Primary Central Nervous System Lymphoma
Kim, Peter
Omuro, Antonio
[J]. CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2020, 21 (09)
[25] Primary CNS lymphoma at first relapse/progression: characteristics, management, and outcome of 256 patients from the French LOC network
Langner-Lemercier, Sophie
Houillier, Caroline
Soussain, Carole
Ghesquieres, Herve
Chinot, Olivier
Taillandier, Luc
Soubeyran, Pierre
Lamy, Thierry
Morschhauser, Franck
Benouaich-Amiel, Alexandra
Ahle, Guido
Moles-Moreau, Marie-Pierre
Molucon-Chabrot, Cecile
Bourquard, Pascal
Damaj, Ghandi
Jardin, Fabrice
Larrieu, Delphine
Gyan, Emmanuel
Gressin, Remy
Jaccard, Arnaud
Choquet, Sylvain
Brion, Annie
Casasnovas, Olivier
Colin, Philippe
Reman, Oumedaly
Tempescul, Adrian
Marolleau, Jean-Pierre
Fabbro, Michel
Naudet, Florian
Hoang-Xuan, Khe
Houot, Roch
[J]. NEURO-ONCOLOGY, 2016, 18 (09) : 1297 - 1303
[26] Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT)
Mohty, M.
Malard, F.
Abecassis, M.
Aerts, E.
Alaskar, A. S.
Aljurf, M.
Arat, M.
Bader, P.
Baron, F.
Bazarbachi, A.
Blaise, D.
Ciceri, F.
Corbacioglu, S.
Dalle, J-H
Duarte, R. F.
Fukuda, T.
Huynh, A.
Masszi, T.
Michallet, M.
Nagler, A.
NiChonghaile, M.
Pagluica, T.
Peters, C.
Petersen, F. B.
Richardson, P. G.
Ruutu, T.
Savani, B. N.
Wallhult, E.
Yakoub-Agha, I.
Carreras, E.
[J]. BONE MARROW TRANSPLANTATION, 2015, 50 (06) : 781 - 789
[27] Rituximab, Methotrexate, Procarbazine, and Vincristine Followed by Consolidation Reduced-Dose Whole-Brain Radiotherapy and Cytarabine in Newly Diagnosed Primary CNS Lymphoma: Final Results and Long-Term Outcome
Morris, Patrick G.
Correa, Denise D.
Yahalom, Joachim
Raizer, Jeffrey J.
Schiff, David
Grant, Barbara
Grimm, Sean
Lai, Rose K.
Reiner, Anne S.
Panageas, Kathy
Karimi, Sasan
Curry, Richard
Shah, Gaurav
Abrey, Lauren E.
DeAngelis, Lisa M.
Omuro, Antonio
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (31) : 3971 - +
[28] Delayed neurotoxicity in primary central nervous system lymphoma
Omuro, AMP
Ben-Porat, LS
Panageas, KS
Kim, AK
Correa, DD
Yahalom, J
DeAngelis, LM
Abrey, LE
[J]. ARCHIVES OF NEUROLOGY, 2005, 62 (10) : 1595 - 1600
[29] Intensive Chemotherapy and Immunotherapy in Patients With Newly Diagnosed Primary CNS Lymphoma: CALGB 50202 (Alliance 50202)
Rubenstein, James L.
Hsi, Eric D.
Johnson, Jeffrey L.
Jung, Sin-Ho
Nakashima, Megan O.
Grant, Barbara
Cheson, Bruce D.
Kaplan, Lawrence D.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (25) : 3061 - +
[30] Outcomes of Consecutively Diagnosed Primary Central Nervous System Lymphoma Patients Using the Alberta Lymphoma Clinical Practice Guideline Incorporating Thiotepa-Busulfan Conditioning for Transplantation-Eligible Patients
Sanders, Sheilagh
Chua, Neil
Larouche, Jean-Francois
Owen, Carolyn
Shafey, Mona
Stewart, Douglas A.
[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2019, 25 (08) : 1505 - 1510

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