Regulation of cholesterol homeostasis by liver X receptors

被引：40
作者：
Hu, Yan-Wei [1 ]
Zheng, Lei [1 ]
Wang, Qian [1 ]
机构：
[1] So Med Univ, Nanfang Hosp, Lab Med Ctr, Guangzhou 510515, Guangdong, Peoples R China
来源：
CLINICA CHIMICA ACTA | 2010年 / 411卷 / 9-10期
关键词：
Cholesterol homeostasis; Atherosclerosis; LXRs; HDL; RCT; PHOSPHOLIPID TRANSFER PROTEIN; DENSITY-LIPOPROTEIN RECEPTOR; CASSETTE TRANSPORTER A1; HUMAN-ENDOTHELIAL-CELLS; CORONARY-HEART-DISEASE; APOLIPOPROTEIN-E; LXR-ALPHA; IN-VIVO; DEFICIENT MICE; ATHEROSCLEROTIC LESIONS;
D O I：
10.1016/j.cca.2009.12.027
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Cellular cholesterol levels reflect a balance between uptake, efflux, and endogenous synthesis. The sterol-responsive transcription factors liver X receptors (LXR alpha and LXR beta) help maintain cholesterol homeostasis, not only through promotion of cholesterol efflux from peripheral tissues but also through suppression of de novo synthesis and exogenous cholesterol uptake. In this review, we summarize the important role of LXRs in regulating expression of key members that keep cholesterol levels in balance. (C) 2010 Published by Elsevier B.V.
引用
收藏
页码：617 / 625
页数：9
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