Box H/ACA Small Ribonucleoproteins

被引：192
作者：
Kiss, Tamas [1 ,2 ]
Fayet-Lebaron, Eleonore [1 ]
Jady, Beata E. [1 ]
机构：
[1] Univ Toulouse 3, CNRS, Lab Biol Mol Eucaryote,UMR5099, IFR109, F-31062 Toulouse 9, France
[2] Hungarian Acad Sci, Biol Res Ctr, H-6726 Szeged, Hungary
来源：
MOLECULAR CELL | 2010年 / 37卷 / 05期
关键词：
HUMAN TELOMERASE RNA; BODY-SPECIFIC LOCALIZATION; SMALL NUCLEOLAR RNAS; SMALL NUCLEAR RNAS; PSEUDOURIDINE SYNTHASE; CAJAL BODIES; CRYSTAL-STRUCTURE; NONCODING RNAS; SUBSTRATE RNA; SECONDARY STRUCTURE;
D O I：
10.1016/j.molcel.2010.01.032
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Box H/ACA RNAs represent an abundant, evolutionarily conserved class of small noncoding RNAs. All H/ACA RNAs associate with a common set of proteins, and they function as ribonucleoprotein (RNP) enzymes mainly in the site-specific pseudouridylation of ribosomal RNAs (rRNAs) and small nuclear RNAs (snRNAs). Some H/ACA RNPs function in the nucleolytic processing of precursor rRNA (pre-rRNA) and synthesis of telomeric DNA. Thus, H/ACA RNPs are essential for three fundamental cellular processes: protein synthesis, mRNA splicing, and maintenance of genome integrity. Recently, great progress has been made toward understanding of the biogenesis, intracellular trafficking, structure, and function of H/ACA RNPs.
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收藏
页码：597 / 606
页数：10
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