Efficacy of Bifidobacterium bifidum G9-1 in improving quality of life in patients with chronic constipation: a prospective intervention study

被引:8
作者
Fuyuki, Akiko [1 ]
Higurashi, Takuma [1 ]
Kessoku, Takaomi [1 ]
Ashikari, Keiichi [1 ]
Yoshihara, Tsutomu [1 ]
Misawa, Noboru [1 ]
Iwaki, Michihiro [1 ]
Kobayashi, Takashi [1 ]
Ohkubo, Hidenori [1 ]
Yoneda, Masato [1 ]
Usuda, Haruki [2 ]
Wada, Koichiro [2 ]
Nakajima, Atsushi [1 ]
机构
[1] Yokohama City Univ, Dept Gastroenterol & Hepatol, Sch Med, Kanazawa Ku, 3-9 Fuku Ura, Yokohama, Kanagawa 2360004, Japan
[2] Shimane Univ, Dept Pharmacol, Fac Med, 89-1 Enyacho, Izumo, Shimane 6930021, Japan
关键词
Bifidobacterium bifidum G9-1; chronic constipation; clinical trial; probiotic; quality of life; GUT MICROBIOTA; PROBIOTICS; BACTERIA; TRANSIT; METHANE;
D O I
10.12938/bmfh.2020-073
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Chronic constipation is a functional disorder that decreases a patient's quality of life (QOL). Because dysbiosis has been associated with constipation, we aimed to investigate the efficacy of Bifidobacterium bifidum G9-1 (BBG91) in improving QOL in patients with constipation. This was a prospective, single-center, non-blinded, single-arm feasibility trial. A total of 31 patients with constipation and decreased QOL received BBG9-1 treatment for 8 weeks, followed by a 2-week washout period. The primary endpoint was change in the overall Japanese version of the patient assessment of constipation of QOL (JPAC-QOL) score after probiotic administration relative to that at baseline. Secondary endpoints included changes in gut microbiota, stool consistency, frequency of bowel movement, degree of straining, sensation of incomplete evacuation, and frequency of rescue drug use. The overall JPAC-QOL scores and frequency of bowel movement significantly improved after BBG9-1 administration from those at baseline (p<0.01 and p<0.01, respectively). There were no statistically significant changes in other clinical symptoms. Subset analysis revealed that patients with initial Bristol Stool Form Scale stool types of <4 had improvements in stool consistency, a significant increase in the frequency of bowel movements, and a significant alleviation in the degree of straining, following BBG9-1 administration. At the genus and species levels, Sarcina and Sarcina maxima were significantly increased. Functional analysis showed that butanoate metabolism increased significantly, whereas methane metabolism decreased significantly. We concluded that BBG9-1 is safe and improves QOL in patients with constipation. The underlying improvements may be due to changes in stool consistency.
引用
收藏
页码:105 / 114
页数:10
相关论文
共 31 条
  • [1] Chronic constipation: A critical review
    Basilisco, Guido
    Coletta, Marina
    [J]. DIGESTIVE AND LIVER DISEASE, 2013, 45 (11) : 886 - 893
  • [2] Mechanisms of Action of Probiotics and the Gastrointestinal Microbiota on Gut Motility and Constipation
    Dimidi, Eirini
    Christodoulides, Stephanos
    Scott, S. Mark
    Whelan, Kevin
    [J]. ADVANCES IN NUTRITION, 2017, 8 (03) : 484 - 494
  • [3] The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials
    Dimidi, Eirini
    Christodoulides, Stephanos
    Fragkos, Konstantinos C.
    Scott, S. Mark
    Whelan, Kevin
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2014, 100 (04) : 1075 - 1084
  • [4] An improved dual-indexing approach for multiplexed 16S rRNA gene sequencing on the Illumina MiSeq platform
    Fadrosh, Douglas W.
    Ma, Bing
    Gajer, Pawel
    Sengamalay, Naomi
    Ott, Sandra
    Brotman, Rebecca M.
    Ravel, Jacques
    [J]. MICROBIOME, 2014, 2
  • [5] The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic
    Hill, Colin
    Guarner, Francisco
    Reid, Gregor
    Gibson, Glenn R.
    Merenstein, Daniel J.
    Pot, Bruno
    Morelli, Lorenzo
    Canani, Roberto Berni
    Flint, Harry J.
    Salminen, Seppo
    Calder, Philip C.
    Sanders, Mary Ellen
    [J]. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2014, 11 (08) : 506 - 514
  • [6] Isa Y, 2003, JPN J MED PHARM SCI, V49, P745
  • [7] Chronic constipation: a survey of the patient perspective
    Johanson, J. F.
    Kralstein, J.
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2007, 25 (05) : 599 - 608
  • [8] Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipation
    Khalif, IL
    Quigley, EMM
    Konovitch, EA
    Maximova, ID
    [J]. DIGESTIVE AND LIVER DISEASE, 2005, 37 (11) : 838 - 849
  • [9] Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation
    Koebnick, C
    Wagner, I
    Leitzmann, P
    Stern, U
    Zunft, HJF
    [J]. CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2003, 17 (11): : 655 - 659
  • [10] Bowel Disorders
    Lacy, Brian E.
    Mearin, Fermin
    Chang, Lin
    Chey, William D.
    Lembo, Anthony J.
    Simren, Magnus
    Spiller, Robin
    [J]. GASTROENTEROLOGY, 2016, 150 (06) : 1393 - +