Novel deoxy-selenylconduritols: chemoenzymatic synthesis and biological evaluation

被引：10

作者：

Bellomo, Ana ^{[1
]}

Bertucci, Ana ^{[2
]}

Stefani, Helio ^{[3
,4
]}

Vazquez, Alvaro ^{[2
]}

Gonzalez, David ^{[1
]}

机构：

[1] Univ Republica, UdelaR, Fac Quim, Lab Sintesis Organ, Montevideo, Uruguay

[2] Univ Republica, UdelaR, Fac Quim, Lab Farmacognosia & Prod Nat, Montevideo, Uruguay

[3] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo, Brazil

[4] Univ Fed Sao Paulo, Dept Biofis, Sao Paulo, Brazil

来源：

TETRAHEDRON-ASYMMETRY | 2009年 / 20卷 / 23期

基金：

巴西圣保罗研究基金会;

关键词：

EFFICIENT SYNTHESIS; (-)-CONDURITOL C; CONDURITOL; CYCLITOLS; SELENIUM; CONDURAMINE; DERIVATIVES; HYDROLYSIS; EPOXIDES; ANALOGS;

D O I：

10.1016/j.tetasy.2009.11.004

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The first synthesis of two selenyldeoxycyclitols (4-bromo-2-phenylselenyl conduritol F and 6-phenylselenylconduritol F) is reported via a chemoenzymatic enantioselective route. The key step of the synthesis is the selenolysis of a vinyl epoxide. The new compounds were evaluated for their capacity to inhibit the growth of different microorganisms using a modification of the agar diffusion technique with thin layer chromatography plates as support. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2673 / 2676

页数：4

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