Increased ethanol intake after prenatal ethanol exposure: Studies with animals

被引:93
作者
Chotro, M. Gabriela [1 ]
Arias, Carlos
Laviola, Giovanni
机构
[1] Univ Basque Country, EHU, San Sebastian, Spain
[2] Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy
关键词
prenatal ethanol exposure; ethanol preference; intake; teratological effects; rodents; associative learning; FETAL ALCOHOL SYNDROME; CONDITIONED TASTE-AVERSION; HYPERACTIVE CHILD SYNDROME; SLEEP-WAKE BEHAVIOR; RAT FETUS; AMNIOTIC-FLUID; PREGNANT RATS; ADULT-RATS; MATERNAL CONSUMPTION; ENDOGENOUS OPIOIDS;
D O I
10.1016/j.neubiorev.2006.06.021
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
This review analyses the most relevant studies in which ethanol intake was measured after prenatal exposure to the drug. Despite the variety in methodology, in most such studies this prenatal experience induced a higher consumption of ethanol. Several variables that may affect the expression of this phenomenon are discussed, such as gender, age at testing, period of ethanol exposure, ethanol dose and conditions during the test. The mechanisms proposed in all these studies to explain the increased ethanol intake effect are also discussed. Some of these mechanisms are related to the teratological effects of the drug on the neurochemical systems involved in the reinforcing effects of abuse drugs, as well as on the regulatory systems of stress response. Another explanation of this phenomenon is also proposed in terms of associative learning. Specifically, the increased ethanol intake effect may be the result of a conditioned preference for ethanol acquired by the fetus when exposed to the drug during the last days of gestation. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:181 / 191
页数:11
相关论文
共 119 条
[1]   EXPOSURE OF RATS TO ALCOHOL INUTERO ALTERS DRUG SENSITIVITY IN ADULTHOOD [J].
ABEL, EL ;
BUSH, R ;
DINTCHEFF, BA .
SCIENCE, 1981, 212 (4502) :1531-1533
[2]   ABSENCE OF EFFECT OF PRENATAL ETHANOL ON ADULT EMOTIONALITY AND ETHANOL-CONSUMPTION IN RATS [J].
ABEL, EL ;
YORK, JL .
JOURNAL OF STUDIES ON ALCOHOL, 1979, 40 (07) :547-553
[3]   INUTERO ALCOHOL HEIGHTENS JUVENILE REACTIVITY [J].
ANANDAM, N ;
FELEGI, W ;
STERN, JM .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1980, 13 (04) :531-535
[4]   PRENATAL EXPOSURE TO ETHANOL ALTERS THE ONTOGENY OF THE BETA-ENDORPHIN RESPONSE TO STRESS [J].
ANGELOGIANNI, P ;
GIANOULAKIS, C .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1989, 13 (04) :564-571
[5]  
[Anonymous], FETAL DEV PSYCHOBIOL
[6]   Increased palatability of ethanol after prenatal ethanol exposure is mediated by the opioid system [J].
Arias, C ;
Chotro, MG .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2005, 82 (03) :434-442
[7]   Increased preference for ethanol in the infant rat after prenatal ethanol exposure, expressed on intake and taste reactivity tests [J].
Arias, C ;
Chotro, MG .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2005, 29 (03) :337-346
[8]   Ethanol-induced preferences or aversions as a function of age in preweanling rats [J].
Arias, Carlos ;
Chotro, M. Gabriela .
BEHAVIORAL NEUROSCIENCE, 2006, 120 (03) :710-718
[9]   CONDITIONED OPIOID ACTIVITY IN THE RAT FETUS [J].
ARNOLD, HM ;
ROBINSON, SR ;
SPEAR, NE ;
SMOTHERMAN, WP .
BEHAVIORAL NEUROSCIENCE, 1993, 107 (06) :963-969
[10]   Prenatal alcohol exposure and family history of alcoholism in the etiology of adolescent alcohol problems [J].
Baer, JS ;
Barr, HM ;
Bookstein, FL ;
Sampson, PD ;
Streissguth, AP .
JOURNAL OF STUDIES ON ALCOHOL, 1998, 59 (05) :533-543