Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes

被引：38
作者：
Chen, Wenqing [1 ,2 ]
Qi, Jianzhao [1 ,2 ]
Wu, Pan [1 ,2 ]
Wan, Dan [1 ,2 ]
Liu, Jin [1 ,2 ]
Feng, Xuan [1 ,2 ]
Deng, Zixin [1 ,2 ,3 ,4 ]
机构：
[1] Wuhan Univ, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Peoples R China
[2] Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China
[3] Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200030, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200030, Peoples R China
来源：
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | 2016年 / 43卷 / 2-3期
基金：
美国国家科学基金会;
关键词：
Nucleoside antibiotics; Natural products; Post-genomic era; Synthetic biology; BACTERIAL TRANSLOCASE-I; STREPTOMYCES-TENDAE TU901; GENE-CLUSTER; HETEROLOGOUS EXPRESSION; NIKKOMYCIN BIOSYNTHESIS; MOLECULAR ANALYSIS; PACIDAMYCIN GROUP; BOND FORMATION; PUR CLUSTER; IDENTIFICATION;
D O I：
10.1007/s10295-015-1636-3
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Nucleoside antibiotics constitute an important family of microbial natural products bearing diverse bioactivities and unusual structural features. Their biosynthetic logics are unique with involvement of complex multi-enzymatic reactions leading to the intricate molecules from simple building blocks. Understanding how nature builds this family of antibiotics in post-genomic era sets the stage for rational enhancement of their production, and also paves the way for targeted persuasion of the cell factories to make artificial designer nucleoside drugs and leads via synthetic biology approaches. In this review, we discuss the recent progress and perspectives on the natural and engineered biosynthesis of nucleoside antibiotics.
引用
收藏
页码：401 / 417
页数：17
相关论文
共 97 条
  • [1] Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis: Discovery of an L-Threonine:Uridine-5′-Aldehyde Transaldolase
    Barnard-Britson, Sandra
    Chi, Xiuling
    Nonaka, Koichi
    Spork, Anatol P.
    Tibrewal, Nidhi
    Goswami, Anwesha
    Pahari, Pallab
    Ducho, Christian
    Rohr, Jurgen
    Van Lanen, Steven G.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (45) : 18514 - 18517
  • [2] Cloning and heterologous expression of the entire set of structural genes for nikkomycin synthesis from Streptomyces tendae Tu901 in Streptomyces lividans
    Bormann, C
    Mohrle, V
    Bruntner, C
    [J]. JOURNAL OF BACTERIOLOGY, 1996, 178 (04) : 1216 - 1218
  • [3] The Streptomyces tendae Tu901 L-lysine 2-aminotransferase catalyzes the initial reaction in nikkomycin D biosynthesis
    Bruntner, C
    Bormann, C
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 254 (02): : 347 - 355
  • [4] Biosynthesis of Streptolidine Involved Two Unexpected Intermediates Produced by a Dihydroxylase and a Cyclase through Unusual Mechanisms
    Chang, Chin-Yuan
    Lyu, Syue-Yi
    Liu, Yu-Chen
    Hsu, Ning-Shian
    Wu, Chih-Chung
    Tang, Cheng-Fong
    Lin, Kuan-Hung
    Ho, Jin-Yuan
    Wu, Chang-Jer
    Tsai, Ming-Daw
    Li, Tsung-Lin
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (07) : 1943 - 1948
  • [5] Formation of β-hydroxy histidine in the biosynthesis of nikkomycin antibiotics
    Chen, H
    Hubbard, BK
    O'Connor, SE
    Walsh, CT
    [J]. CHEMISTRY & BIOLOGY, 2002, 9 (01): : 103 - 112
  • [6] Characterizing Amosamine Biosynthesis in Amicetin Reveals AmiG as a Reversible Retaining Glycosyltransferase
    Chen, Ruidong
    Zhang, Haibo
    Zhang, Gaiyun
    Li, Sumei
    Zhang, Guangtao
    Zhu, Yiguang
    Liu, Jinsong
    Zhang, Changsheng
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (33) : 12152 - 12155
  • [7] Genetic dissection of the polyoxin building block-carbamoylpolyoxamic acid biosynthesis revealing the "pathway redundancy" in metabolic networks
    Chen, Wenqing
    Dai, Daofeng
    Wang, Changchun
    Huang, Tingting
    Zhai, Lipeng
    Deng, Zixin
    [J]. MICROBIAL CELL FACTORIES, 2013, 12
  • [8] Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis
    Chen, Wenqing
    Qu, Dongjing
    Zhai, Lipeng
    Tao, Meifeng
    Wang, Yemin
    Lin, Shuangjun
    Price, Neil P. J.
    Deng, Zixin
    [J]. PROTEIN & CELL, 2010, 1 (12) : 1093 - 1105
  • [9] Characterization of the Polyoxin Biosynthetic Gene Cluster from Streptomyces cacaoi and Engineered Production of Polyoxin H
    Chen, Wenqing
    Huang, Tingting
    He, Xinyi
    Meng, Qingqing
    You, Delin
    Bai, Linquan
    Li, Jialiang
    Wu, Mingxuan
    Li, Rui
    Xie, Zhoujie
    Zhou, Huchen
    Zhou, Xiufen
    Tan, Huarong
    Deng, Zixin
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (16) : 10627 - 10638
  • [10] Identification of the gene cluster involved in muraymycin biosynthesis from Streptomyces sp NRRL 30471
    Cheng, Lin
    Chen, Wenqing
    Zhai, Lipeng
    Xu, Dongmei
    Huang, Tingting
    Lin, Shuangjun
    Zhou, Xiufen
    Deng, Zixin
    [J]. MOLECULAR BIOSYSTEMS, 2011, 7 (03) : 920 - 927
12345678910