Plasma Homocysteine Level Is Independently Associated With Conventional Atherogenic Lipid Profile and Remnant Cholesterol in Adults

被引:9
作者
Zhou, Liyuan [1 ]
Liu, Jia [1 ]
An, Yu [1 ]
Wang, Ying [2 ]
Wang, Guang [1 ]
机构
[1] Capital Med Univ, Beijing Chao Yang Hosp, Dept Endocrinol, Beijing, Peoples R China
[2] Capital Med Univ, Beijing Chao Yang Hosp, Med Examinat Ctr, Beijing, Peoples R China
来源
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2022年 / 9卷
基金
中国国家自然科学基金;
关键词
homocysteine; high-density lipoprotein cholesterol; apolipoprotein A1; triglyceride; remnant cholesterol; Chinese adults; DENSITY-LIPOPROTEIN CHOLESTEROL; RESIDUAL CARDIOVASCULAR RISK; ENDOPLASMIC-RETICULUM STRESS; TYPE-2; DIABETIC-PATIENTS; FOLIC-ACID; LDL CHOLESTEROL; SERUM HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; DISEASE; SUPPLEMENTATION;
D O I
10.3389/fcvm.2022.898305
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundHomocysteine (Hcy) is an independent risk factor for cardiovascular disease, while mechanisms are unclear. Despite inconsistent and limited, epidemiological and experimental studies indicated that hyperhomocysteinemia (HHcy) affected lipid metabolism. This study aims to investigate the association of plasma Hcy with traditional lipid profiles and remnant cholesterol (RC) in Chinese adults. MethodsIn total, 7,898 subjects aged 20-79 years who underwent a physical examination at Beijing Chao-Yang Hospital in Beijing were included in this study. Fasting plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), lipoprotein (a) [Lp(a)], Hcy, and other metabolic risk factors were measured by routine automated laboratory methods. RC was calculated as TC minus HDL-C and LDL-C. The linear regression model and logistic regression model were used to assess the relationship between Hcy and lipids after adjusting potential confounders. ResultsOf the subjects, the median level of plasma Hcy was 13.0 mu mol/L and 32.3% had HHcy. Plasma Hcy was negatively associated with HDL-C, ApoA1, and Lp(a) and positively associated with TG levels after adjusting age, sex, body mass index, blood pressure, alanine transaminase, aspartate transaminase, creatinine, uric acid, and glucose. HHcy significantly increased the risk of low HDL-C [odds ratio (OR) 1.26; 95%CI (1.11-1.44); p < 0.001]. The net mediation effects of ApoA1 on the relationship between Hcy and HDL-C before and after adjusting confounders were 46.9 and 30.6%, respectively. More interestingly, the RC level was significantly elevated in subjects with HHcy after adjusting other influencing factors (p = 0.025). Hcy presented a positive correlation with RC levels after adjusting the above confounding factors (beta = 0.073, p = 0.004), and the correlation was still significant even after controlling other lipids, including TG, LDL-C, HDL-C, ApoA1, ApoB, and Lp(a). ConclusionOur study showed that plasma Hcy was not only significantly associated with conventional atherogenic lipids but also independently correlated with RC levels beyond other lipids after controlling potential confounders. This finding proposes that identifying Hcy-related dyslipidemia risk, both traditional lipids and RC residual risk, is clinically relevant as we usher in a new era of targeting Hcy-lowering therapies to fight against dyslipidemia or even cardiovascular disease.
引用
收藏
页数:11
相关论文
共 70 条
  • [2] Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
    Asbaghi, Omid
    Ashtary-Larky, Damoon
    Bagheri, Reza
    Nazarian, Behzad
    Olyaei, Hadi Pourmirzaei
    Kelishadi, Mahnaz Rezaei
    Nordvall, Michael
    Wong, Alexei
    Dutheil, Frederic
    Naeini, Amirmansour Alavi
    [J]. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2022, 62 (30) : 8435 - 8453
  • [3] Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials
    Baigent, C.
    Blackwell, L.
    Emberson, J.
    Holland, L. E.
    Reith, C.
    Bhala, N.
    Peto, R.
    Barnes, E. H.
    Keech, A.
    Simes, J.
    Collins, R.
    [J]. LANCET, 2010, 376 (9753) : 1670 - 1681
  • [4] Homocysteine and cardiovascular disease - Is HDL the link?
    Barter, Philip J.
    Rye, Kerry-Anne
    [J]. CIRCULATION RESEARCH, 2006, 99 (06) : 565 - 566
  • [5] The Impact of Supplementation with Folic Acid on Homocysteine Concentration and Selected Lipoprotein Parameters in Patients with Primary Hypertension
    Baszczuk, Aleksandra
    Thielemann, Anna
    Muslalik, Katarzyna
    Kopczynski, Jaroslaw
    Bielawska, Lena
    Mzumak, Anna
    Kopczynski, Zygmunt
    Wysocka, Ewa
    [J]. JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 2017, 63 (02) : 96 - 103
  • [6] A QUANTITATIVE ASSESSMENT OF PLASMA HOMOCYSTEINE AS A RISK FACTOR FOR VASCULAR-DISEASE - PROBABLE BENEFITS OF INCREASING FOLIC-ACID INTAKES
    BOUSHEY, CJ
    BERESFORD, SAA
    OMENN, GS
    MOTULSKY, AG
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (13): : 1049 - 1057
  • [7] Remnant Cholesterol, Not LDL Cholesterol, Is Associated With Incident Cardiovascular Disease
    Castaner, Olga
    Pinto, Xavier
    Subirana, Isaac
    Amor, Antonio J.
    Ros, Emilio
    Hernaez, Alvaro
    Angel Martinez-Gonzalez, Miguel
    Corella, Dolores
    Salas-Salvado, Jordi
    Estruch, Ramon
    Lapetra, Jose
    Gomez-Gracia, Enrique
    Alonso-Gomez, Angel M.
    Fiol, Miquel
    Serra-Majem, Lluis
    Corbella, Emili
    Benaiges, David
    Sorli, Jose V.
    Ruiz-Canela, Miguel
    Babio, Nancy
    Sierra, Lucas Tojal
    Ortega, Emilio
    Fito, Montserrat
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 76 (23) : 2712 - 2724
  • [8] HYPERHOMOCYSTEINEMIA - AN INDEPENDENT RISK FACTOR FOR VASCULAR-DISEASE
    CLARKE, R
    DALY, L
    ROBINSON, K
    NAUGHTEN, E
    CAHALANE, S
    FOWLER, B
    GRAHAM, I
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (17) : 1149 - 1155
  • [9] Folic acid attenuates homocysteine and enhances antioxidative capacity in atherosclerotic rats
    Cui, Shanshan
    Li, Wen
    Lv, Xin
    Wang, Pengyan
    Huang, Guowei
    Gao, Yuxia
    [J]. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, 2017, 42 (10) : 1015 - 1022
  • [10] Total homocysteine levels relation with chronic complications of diabetes, body composition, and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2
    de Luis, DA
    Fernandez, N
    Arranz, ML
    Aller, R
    Izaola, O
    Romero, E
    [J]. JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2005, 19 (01) : 42 - 46