The inhibition of diacylglycerol acyltransferase by terpenoids from Youngia koidzumiana

被引：24

作者：

Dat, NT

Cai, XF

Rho, MC

Lee, HS

Bae, K

Kim, YH ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Cardiovasc Res Lab, Taejon 305600, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2005年 / 28卷 / 02期

关键词：

Youngia koidzumiana; germanicol acetate; brachynereolide; ixerin Y; methylursolate; corosolic acid; crepidiaside C; diacylglycerol acyltransferase;

D O I：

10.1007/BF02977708

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The EtOAc extract of Youngia koidzumiana significantly inhibited the diacylglycerol acyltransferase (DGAT) from rat liver microsomes. Bioactivity-guided fractionation led to the isolation of nine compounds, the structures of which were established using physicochemical and spectral data. Of the isolated compounds, oleanolic acid (2), methyl ursolate (7) and corosolic aicd (8) inhibited DGAT, with IC50 values of 31.7, 26.4, and 44.3 muM, respectively. However, sesquiterpenoids showed only weak inhibitory effects toward DGAT.

引用

页码：164 / 168

页数：5

共 16 条

[1]

ADEGAWA S, 1985, CHEM PHARM BULL, V33, P4906

[2] Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis [J].

Cases, S ;

Smith, SJ ;

Zheng, YW ;

Myers, HM ;

Lear, SR ;

Sande, E ;

Novak, S ;

Collins, C ;

Welch, CB ;

Lusis, AJ ;

Erickson, SK ;

Farese, RV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13018-13023

[3]

COLEMAN RA, 1992, METHOD ENZYMOL, V209, P98

[4]

DAT NT, 2002, NAT PROD SCI, V8, P55

[5]

GRAY GA, 2000, CURR OPIN LIPIDOL, V11, P229

[6]

KANG SS, 2000, STRUCTURE DETERMINAT

[7] Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa [J].

Ko, JS ;

Rho, MC ;

Chung, MY ;

Song, HY ;

Kang, JS ;

Kim, K ;

Lee, HS ;

Kim, YK .

PLANTA MEDICA, 2002, 68 (12) :1131-1133

[8] Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza [J].

Ko, JS ;

Ryu, SY ;

Kim, YS ;

Chung, MY ;

Kang, JS ;

Rho, MC ;

Lee, HS ;

Kim, YK .

ARCHIVES OF PHARMACAL RESEARCH, 2002, 25 (04) :446-448

[9]

KOZIMA H, 1989, PHYTOCHEMISTRY, V28, P1703

[10]

KUANG HX, 1989, CHEM PHARM BULL, V37, P2232

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