Evidence connecting old, new and neglected glucose-lowering drugs to bile acid-induced GLP-1 secretion: A review

被引:16
作者
Karhus, Martin L. [1 ]
Bronden, Andreas [1 ]
Sonne, David P. [1 ,2 ]
Vilsboll, Tina [1 ,3 ,5 ]
Knop, Fillip K. [1 ,3 ,4 ]
机构
[1] Univ Copenhagen, Gentofte Hosp, Ctr Diabet Res, Kildegardsvej 28, DK-2900 Hellerup, Denmark
[2] Univ Copenhagen, Bispebjerg Hosp, Dept Clin Pharmacol, Copenhagen, Denmark
[3] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark
[4] Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark
[5] Univ Copenhagen, Steno Diabet Ctr Copenhagen, Gentofte, Denmark
关键词
antidiabetic drug; ASBT inhibitors; bile acid; bile acid sequestrants; drug mechanism; GLP-1; incretin therapy; metformin; type; 2; diabetes; GLUCAGON-LIKE PEPTIDE-1; TYPE-2; DIABETES-MELLITUS; PANCREATIC BETA-CELLS; GLYCEMIC CONTROL; COLESEVELAM HYDROCHLORIDE; INSULIN SENSITIVITY; DOUBLE-BLIND; METFORMIN; THERAPY; RECEPTOR;
D O I
10.1111/dom.12946
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Bile acids are amphipathic water-soluble steroid-based molecules best known for their important lipid-solubilizing role in the assimilation of fat. Recently, bile acids have emerged as metabolic integrators with glucose-lowering potential. Among a variety of gluco-metabolic effects, bile acids have been demonstrated to modulate the secretion of the gut-derived incretin hormone glucagon-like peptide-1 (GLP-1), possibly via the transmembrane receptor Takeda G-protein-coupled receptor 5 and the nuclear farnesoid X receptor, in intestinal L cells. The present article critically reviews current evidence connecting established glucose-lowering drugs to bile acid-induced GLP-1 secretion, and discusses whether bile acid-induced GLP-1 secretion may constitute a new basis for understanding how metformin, inhibitors of the apical sodium-dependent bile acids transporter, and bile acid sequestrants - old, new and neglected glucose-lowering drugs - improve glucose metabolism.
引用
收藏
页码:1214 / 1222
页数:9
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