The Protective Effect of 1,25(OH)2D3 on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism

被引：11

作者：

Yang, Jingxin ^{[1
]}

Zhang, Yalin ^{[1
]}

Pan, Yiming ^{[1
]}

Sun, Can ^{[1
]}

Liu, Zuwang ^{[1
]}

Liu, Ning ^{[1
]}

Fu, Yu ^{[1
]}

Li, Xiaofeng ^{[1
]}

Li, Ye ^{[1
]}

Kong, Juan ^{[1
]}

机构：

[1] China Med Univ, Shengjing Hosp, Dept Clin Nutr, Shenyang, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

基金：

中国国家自然科学基金;

关键词：

Vitamin D; fatty acid metabolism; Sirtuin; 3; mitochondria; cardiac function;

D O I：

10.3389/fcell.2021.627135

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Energy substrate imbalance is a major cause of cardiac dysfunction. Vitamin D/vitamin D receptor (VD/VDR) deficiency is involved in the pathogenesis of various cardiac diseases; however, the exact underlying mechanism remains unclear. The aim of this study was to investigate whether vitamin D modulates mitochondrial fatty acid oxidase via sirtuin 3 signaling to protect the myocardium. 1-Alpha-hydroxylase-defficient mice exhibited a high metabolic rate and lower myocardial contractility than wild-type mice. Sirtuin 3 upregulation was detected in high-fat diet-fed mice receiving vitamin D3 compared with that in high-fat diet-fed mice. Both sirtuin 3 blockade and knockout inhibited the VD/VDR-induced downregulation of fatty acid oxidase in myocardial mitochondria. VD/VDR suppressed fatty acid metabolism by upregulating sirtuin 3 and lowering mitochondrial fat uptake, thereby improving myocardial function and balancing energy substrates, rather than by altering fat endocytosis and exocytosis.

引用

页数：14

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