Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes

被引：489

作者：

Waterhouse, Robert M.

Kriventseva, Evgenia V.

Meister, Stephan

Xi, Zhiyong

Alvarez, Kanwal S.

Bartholomay, Lyric C.

Barillas-Mury, Carolina

Bian, Guowu

Blandin, Stephanie

Christensen, Bruce M.

Dong, Yuemei

Jiang, Haobo

Kanost, Michael R.

Koutsos, Anastasios C.

Levashina, Elena A.

Li, Jianyong

Ligoxygakis, Petros

MacCallum, Robert M.

Mayhew, George F.

Mendes, Antonio

Michel, Kristin

Osta, Mike A.

Paskewitz, Susan

Shin, Sang Woon

Vlachou, Dina

Wang, Lihui

Wei, Weiqi

Zheng, Liangbiao

Zou, Zhen

Severson, David W.

Raikhel, Alexander S.

Kafatos, Fotis C. ^{[1
]}

Dimopoulos, George

Zdobnov, Evgeny M.

Christophides, George K.

机构：

[1] Univ Geneva, Sch Med, Dept Struct Biol & Bioinformat, CH-1211 Geneva, Switzerland

[2] Univ London Imperial Coll Sci Technol & Med, Fac Nat Sci, Div Cell & Mol Biol, London SW7 2AZ, England

[3] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland

[4] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

[5] Univ Calif Riverside, Dept Entomol, Riverside, CA 92521 USA

[6] Univ Calif Riverside, Inst Integrat Genome Biol, Riverside, CA 92521 USA

[7] Iowa State Univ, Dept Entomol, Ames, IA 50011 USA

[8] NIAID, Lab Malaria & Vector Res, Twinbrook II Facil, NIH, Bethesda, MD 20892 USA

[9] CNRS, Unite Propre Rech 9022, Avnir INSERM, Inst Mol & Cellulaire, Strasbourg, France

[10] Univ Wisconsin, Dept Anim Hlth & Biomed Sci, Madison, WI 53706 USA

[11] Oklahoma State Univ, Dept Entomol & Plant Pathol, Stillwater, OK 74078 USA

[12] Kansas State Univ, Dept Biochem, Manhattan, KS 66506 USA

[13] Virginia Tech, Dept Biochem, Blacksburg, VA 24061 USA

[14] Univ Oxford, Dept Biochem, Oxford OX1 3QU, England

[15] Univ Wisconsin, Dept Entomol, Madison, WI 53706 USA

[16] Yale Univ, Sch Med Epidemiol & Publ Hlth, New Haven, CT 06520 USA

[17] Fujian Ctr Prevent & Control Occupat Dis & Chem P, Fuzhou, Fujian, Peoples R China

[18] Inst Plant Physiol & Ecol, Shanghai, Peoples R China

[19] Univ Notre Dame, Ctr Global Hlth & Infect Dis, Dept Biol Sci, Notre Dame, IN 46556 USA

[20] Swiss Inst Bioinformat, CH-1211 Geneva, Switzerland

来源：

SCIENCE | 2007年 / 316卷 / 5832期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1126/science.1139862

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.

引用

页码：1738 / 1743

页数：6

共 43 条

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