Density functional study of the enzymatic reaction catalyzed by a cyclin-dependent kinase

被引：29

作者：

Cavalli, A ^{[1
]}

De Vivo, M ^{[1
]}

Recanatini, M ^{[1
]}

机构：

[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 11期

关键词：

D O I：

10.1039/b212618d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Density functional theory (DFT) calculations were carried out to study the molecular mechanism of the phosphoryl transfer reaction catalyzed by cyclin-dependent kinases (CDKs). The DFT study presented here shows that CDKs catalyze the phosphoryl transfer reaction from ATP to the serine substrate through a single step mechanism with a S(N)2-like transition state.

引用

页码：1308 / 1309

页数：2

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