Synthetic Applications of Prins Cyclization in Natural Product Syntheses

被引：5

作者：

Tadiparthi, Krishnaji ^{[1
]}

Roy, Allen ^{[1
]}

Sakirolla, Raghavendra ^{[2
,3
]}

Reddy, B. V. Subba ^{[3
]}

Yadav, Jhillu Singh ^{[3
,4
]}

机构：

[1] CHRIST Deemed Univ, Dept Chem, Hosur Rd, Bangalore 560029, Karnataka, India

[2] Cent Univ Karnataka, Dept Chem, Gulbarga 585367, Karnataka, India

[3] CSIR Indian Inst Chem Technol, Fluoro & Agrochem, Hyderabad 500007, India

[4] Indrashil Univ, Sch Sci, Mehsana 382740, Gujarat, India

来源：

CHEMICAL RECORD | 2022年 / 22卷 / 08期

关键词：

Total synthesis; Natural products; Prins reaction; Tetrahyropyran; Chiral pool; STEREOSELECTIVE TOTAL-SYNTHESIS; UNITS;

D O I：

10.1002/tcr.202200044

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The natural products having tetrahydropyran unit with multiple chiral centers serve as magnificent building blocks for various active pharmaceutical ingredients (APIs). 'Prins cyclization is one of the wonderful strategies to construct tetrahydropyran unit stereoselectively in asymmetric synthesis. In this account, we discuss our research efforts toward the synthesis of various natural products from the past two decades (2005-2020) by using Prins cyclization as a key step. Further, the synthetic utility of this reaction was investigated and well demonstrated on various molecules successfully.

引用

页数：35

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