Nodular lesions in diabetic nephropathy: Collagen staining and renal prognosis

被引：20

作者：

Mise, Koki ^{[1
,4
,5
]}

Ueno, Toshiharu ^{[1
]}

Hoshino, Junichi ^{[1
]}

Hazue, Ryo ^{[1
]}

Sumida, Keiichi ^{[1
]}

Yamanouchi, Masayuki ^{[1
]}

Hayami, Noriko ^{[1
]}

Suwabe, Tatsuya ^{[1
]}

Hiramatsu, Rikako ^{[2
]}

Hasegawa, Eiko ^{[2
]}

Sawa, Naoki ^{[2
]}

Fujii, Takeshi ^{[3
]}

Hara, Shigeko ^{[1
,2
,4
]}

Wada, Jun ^{[5
]}

Makino, Hirofumi ^{[5
]}

Takaichi, Kenmei ^{[1
,2
,4
]}

Ohashi, Kenichi ^{[3
,6
]}

Ubara, Yoshifumi ^{[1
,2
,4
]}

机构：

[1] Toranomon Gen Hosp, Nephrol Ctr, Kajigaya, Kanagawa, Japan

[2] Toranomon Gen Hosp, Nephrol Ctr, Tokyo, Japan

[3] Toranomon Gen Hosp, Dept Pathol, Tokyo, Japan

[4] Toranomon Gen Hosp, Okinaka Mem Inst Med Res, Tokyo, Japan

[5] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Nephrol Rheumatol Endocrinol & Metab, Okayama, Japan

[6] Yokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2017年 / 127卷

关键词：

Diabetic nephropathy; Nodular lesion; Renal pathology; Renal prognosis; Type IV collagen; Mesangiolysis; IMMUNOHISTOCHEMICAL LOCALIZATION; TUBULOINTERSTITIAL LESIONS; MESANGIAL MATRIX; MESANGIOLYSIS; BIOPSY; PATHOGENESIS; PROGRESSION; EXPRESSION; GLYCATION; OUTCOMES;

D O I：

10.1016/j.diabres.2017.03.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: Nodular lesions are one of the most characteristic pathological changes of advanced diabetic nephropathy (DN). Previous studies have demonstrated that the pattern of both routine and collagen staining of nodular lesions changes during their development. However, the association between such changes of staining and the renal prognosis remains unclear. Methods: Among 252 patients with biopsy-proven DN, 67 met the selection criteria and were enrolled to investigate this relationship. In all patients, nodular lesions were stained with periodic acid Schiff, periodic acid methenamine silver, and Masson trichrome stains, and immunostaining was done for type I, III, IV, V, and VI collagen. The endpoint was commencement of dialysis due to end-stage renal disease. Results: At least one mesangiolytic nodular lesion (MNL) that showed faint staining for PAS and PAM was found in 61% of the patients. MNLs were negative for type IV collagen staining, unlike the strong positivity of non-MNLs, while type V and VI collagen staining were strongly positive in all nodular lesions. Cox proportional hazards regression analysis revealed that the hazard ratio (HR) for the endpoint was significantly higher in patients with at least one MNL than in patients with no MNLs after adjustment for known promoters of renal progression (HR: 2.94; 95% confidence interval: 1.24-7.07). Conclusions: MNLs may reflect characteristic differences of collagen production and could be a useful prognostic indicator in patients with nodular lesions. Further investigation of the mechanism underlying these differences of collagen production could contribute to finding new therapeutic targets for DN. (C) 2017 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：187 / 197

页数：11

共 35 条

[31] NONENZYMATIC GLYCATION OF MESANGIAL MATRIX AND PROLONGED EXPOSURE OF MESANGIAL MATRIX TO ELEVATED GLUCOSE REDUCES COLLAGEN-SYNTHESIS AND PROTEOGLYCAN CHARGE [J].

SILBIGER, S ;

CROWLEY, S ;

SHAN, Z ;

BROWNLEE, M ;

SATRIANO, J ;

SCHLONDORFF, D .

KIDNEY INTERNATIONAL, 1993, 43 (04) :853-864

[32]

STOUT LC, 1993, HUM PATHOL, V24, P77

[33] Pathologic Classification of Diabetic Nephropathy [J].

Tervaert, Thijs W. Cohen ;

Mooyaart, Antien L. ;

Amann, Kerstin ;

Cohen, Arthur H. ;

Cook, H. Terence ;

Drachenberg, Cinthia B. ;

Ferrario, Franco ;

Fogo, Agnes B. ;

Haas, Mark ;

de Heer, Emile ;

Joh, Kensuke ;

Noel, Laure H. ;

Radhakrishnan, Jai ;

Seshan, Surya V. ;

Bajema, Ingeborg M. ;

Bruijn, Jan A. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2010, 21 (04) :556-563

[34] Nodular lesions and mesangiolysis in diabetic nephropathy [J].

Wada, Takashi ;

Shimizu, Miho ;

Yokoyama, Hitoshi ;

Iwata, Yasunori ;

Sakai, Yoshio ;

Kaneko, Shuichi ;

Furuichi, Kengo .

CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2013, 17 (01) :3-9

[35] Clinical impact of albuminuria in diabetic nephropathy [J].

Wada, Takashi ;

Shimizu, Miho ;

Toyama, Tadashi ;

Hara, Akinori ;

Kaneko, Shuichi ;

Furuichi, Kengo .

CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2012, 16 (01) :96-101

← 1 2 3 4 →