Bone Marrow Expression of Mast Cell Disorders

被引：3

作者：

Sanchez-Munoz, Laura ^{[1
,2
]}

Filipa Henriques, Ana ^{[1
,2
]}

Alvarez-Twose, Ivan ^{[1
,2
]}

Matito, Almudena ^{[1
,2
]}

机构：

[1] Hosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha, Ctra Cobisa S-N, Toledo 45071, Spain

[2] Spanish Network Mastocytosis REMA, Toledo, Spain

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2018年 / 38卷 / 03期

关键词：

Mast cells; Mastocytosis; Flow cytometry; Bone marrow; Cell purification; Diagnosis; KIT mutation; Prognosis; KIT D816V MUTATION; FLOW-CYTOMETRIC ANALYSIS; C-KIT; SYSTEMIC MASTOCYTOSIS; IMMUNOPHENOTYPIC CHARACTERIZATION; SPANISH NETWORK; ACTIVATION SYNDROMES; PERIPHERAL-BLOOD; CATALYTIC DOMAIN; HUMAN BASOPHILS;

D O I：

10.1016/j.iac.2018.04.012

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Mast cell disorders comprise a heterogeneous group of rare diseases, the diagnosis of which still remains a challenge. Bone marrow analysis constitutes the most appropriate site for screening systemic involvement in mastocytosis. Morphologic, immunohistochemical, flow cytometric immunophenotyping, and molecular studies should be routinely performed for diagnostic/prognostic purposes in experienced reference centers during the diagnostic workup in suspected systemic mastocytosis. The authors review the most relevant characteristics of bone marrow expression of mast cell disorders as well as the different methodological approaches to be applied to perform an objective and reproducible diagnosis and classification of mastocytosis and other mast cell disorders.

引用

页码：379 / +

页数：18

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