Inhibitory effect of Murraya koenigii against Candida albicans virulence and biofilm development

被引：10

作者：

Muthamil, Subramanian ^{[1
]}

Pandian, Shunmugiah Karutha ^{[1
]}

机构：

[1] Alagappa Univ, Dept Biotechnol, Sci Campus, Karaikkudi 630004, Tamil Nadu, India

来源：

BIOLOGIA | 2016年 / 71卷 / 03期

关键词：

Candida albicans; biofilm; yeast-to-hyphal transition; drug resistance; Murraya koenigii; ANTIFUNGAL DRUG-RESISTANCE; ASPERGILLUS-FUMIGATUS; SYZYGIUM-AROMATICUM; FUNGAL PATHOGENS; CLINICAL IMPACT; PLANT-PRODUCTS; ESSENTIAL OIL; MECHANISMS; AGENTS; INFECTIONS;

D O I：

10.1515/biolog-2016-0044

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this study, anti-infective potential of the medicinal plant Murraya koenigii was assessed through in vitro assays and microscopic analysis. The methanolic leaf extract of M. koenigii significantly inhibited the major virulence factors of Candida albicans, such as biofilm formation, yeast-to-hyphal transition, cell surface hydrophobicity, hemolysin production and filamentation. Further purification and molecular characterization of the active lead is expected to give a novel anticandidal agent for the treatment of Candida infection.

引用

页码：256 / 264

页数：9

共 63 条

[21] Resistance to antifungal agents: Mechanisms and clinical impact [J].

Kanafani, Zeina A. ;

Perfect, John R. .

CLINICAL INFECTIOUS DISEASES, 2008, 46 (01) :120-128

[22] Biofilm inhibition by Cymbopogon citratus and Syzygium aromaticum essential oils in the strains of Candida albicans [J].

Khan, Mohd Sajjad Ahmad ;

Ahmad, Iqbal .

JOURNAL OF ETHNOPHARMACOLOGY, 2012, 140 (02) :416-423

[23] Hyphal Development in Candida albicans Requires Two Temporally Linked Changes in Promoter Chromatin for Initiation and Maintenance [J].

Lu, Yang ;

Su, Chang ;

Wang, Allen ;

Liu, Haoping .

PLOS BIOLOGY, 2011, 9 (07)

[24] Identification of an antifungal peptide from Trapa natans fruits with inhibitory effects on Candida tropicalis biofilm formation [J].

Mandal, Santi M. ;

Migliolo, Ludovico ;

Franco, Octavio L. ;

Ghosh, Ananta K. .

PEPTIDES, 2011, 32 (08) :1741-1747

[25] PRODUCTION OF A HEMOLYTIC FACTOR BY CANDIDA-ALBICANS [J].

MANNS, JM ;

MOSSER, DM ;

BUCKLEY, HR .

INFECTION AND IMMUNITY, 1994, 62 (11) :5154-5156

[26] INHIBITION OF THE DIMORPHIC TRANSITION OF CANDIDA-ALBICANS BY THE ORNITHINE DECARBOXYLASE INHIBITOR 1,4-DIAMINOBUTANONE - ALTERATIONS IN THE GLYCOPROTEIN COMPOSITION OF THE CELL-WALL [J].

MARTINEZ, JP ;

LOPEZRIBOT, JL ;

GIL, ML ;

SENTANDREU, R ;

RUIZHERRERA, J .

JOURNAL OF GENERAL MICROBIOLOGY, 1990, 136 :1937-1943

[27] Candida albicans pathogenicity mechanisms [J].

Mayer, Francois L. ;

Wilson, Duncan ;

Hube, Bernhard .

VIRULENCE, 2013, 4 (02) :119-128

[28] Inhibition of Candida albicans biofilm formation and yeast-hyphal transition by 4-hydroxycordoin [J].

Messier, Celine ;

Epifano, Francesco ;

Genovese, Salvatore ;

Grenier, Daniel .

PHYTOMEDICINE, 2011, 18 (05) :380-383

[29] White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating [J].

Miller, MG ;

Johnson, AD .

CELL, 2002, 110 (03) :293-302

[30] Inhibition of Candida albicans virulence factors by novel levofloxacin derivatives [J].

Mohamed, Beema Shafreen Raja ;

Subramanian, Muthamil ;

Shunmugiah, Karutha Pandian .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2014, 98 (15) :6775-6785

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