Inhibitory effect of Murraya koenigii against Candida albicans virulence and biofilm development

被引：10

作者：

Muthamil, Subramanian ^{[1
]}

Pandian, Shunmugiah Karutha ^{[1
]}

机构：

[1] Alagappa Univ, Dept Biotechnol, Sci Campus, Karaikkudi 630004, Tamil Nadu, India

来源：

BIOLOGIA | 2016年 / 71卷 / 03期

关键词：

Candida albicans; biofilm; yeast-to-hyphal transition; drug resistance; Murraya koenigii; ANTIFUNGAL DRUG-RESISTANCE; ASPERGILLUS-FUMIGATUS; SYZYGIUM-AROMATICUM; FUNGAL PATHOGENS; CLINICAL IMPACT; PLANT-PRODUCTS; ESSENTIAL OIL; MECHANISMS; AGENTS; INFECTIONS;

D O I：

10.1515/biolog-2016-0044

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this study, anti-infective potential of the medicinal plant Murraya koenigii was assessed through in vitro assays and microscopic analysis. The methanolic leaf extract of M. koenigii significantly inhibited the major virulence factors of Candida albicans, such as biofilm formation, yeast-to-hyphal transition, cell surface hydrophobicity, hemolysin production and filamentation. Further purification and molecular characterization of the active lead is expected to give a novel anticandidal agent for the treatment of Candida infection.

引用

页码：256 / 264

页数：9

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