Notch signaling in lymphopoiesis

被引：71
作者：
Pear, WS
Radtke, F
机构：
[1] Univ Penn, Dept Pathol, Inst Med & Engn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
[2] Univ Lausanne, Ludwig Inst Canc Res, Lausanne Branch, CH-1066 Epalinges, Switzerland
来源：
SEMINARS IN IMMUNOLOGY | 2003年 / 15卷 / 02期
基金：
美国国家卫生研究院;
关键词：
lymphocyte; cell fate; B cell; T cell;
D O I：
10.1016/S1044-5323(03)00003-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Notch signaling regulates many cell fate decisions during development of multi-cellular organisms. Signals initiated by Notch influence a wide variety of processes that include lineage specification, cell survival and proliferation, and border formation. During development of the immune system, Notch has been shown to influence the fate of both hematopoietic stem cells (HSCs) and committed progenitors. Notch appears to play an especially important role in the development of cells that mediate acquired immunity where Notch influences multiple aspects of T and B cell development. In this review, we will focus on the potential functions of Notch signaling during lymphoid development. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：69 / 79
页数：11
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