Bioactive compounds from Smilax excelsa L.

被引：13

作者：

Khaligh, Pooneh ^{[1
]}

Salehi, Peyman ^{[1
]}

Farimani, Mahdi Moridi ^{[1
]}

Ali-Asgari, Safa ^{[2
]}

Esmaeili, Mohammad Ali ^{[3
]}

Ebrahimi, Samad Nejad ^{[1
]}

机构：

[1] Shahid Beheshti Univ, Dept Phytochem, Med Plants & Drugs Res Inst, Tehran, Iran

[2] Islamic Azad Univ, Shahrood Branch, Dept Chem, Fac Sci, Shahrood, Iran

[3] Shahid Beheshti Univ, Dept Biol, Med Plants & Drugs Res Inst, Tehran, Iran

来源：

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2016年 / 13卷 / 06期

关键词：

Smilax excelsa; Violasterol A; Absolute configuration; Cytotoxicity; Antibacterial; ANTIOXIDANT;

D O I：

10.1007/s13738-016-0819-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phytochemical investigation of EtOAc extract of Smilax excelsa has led to isolation and structure elucidation of five compounds. The structures of these compounds are established by different spectroscopic techniques including 1D and 2D-NMR, HRMS and ECD spectroscopy. The compounds were: solanesol (1), violasterol A (2), trans-resveratrol (3), 5-O-caffeoylshikimic acid (4) and 6-O-caffeoyl-beta-d-fructofuranosyl-(2-1)-alpha-d-glucopyranoside (5). The configuration of compound 2 was established by electronic circular dichroism (ECD) spectroscopy. Meanwhile the cytotoxicity and antibacterial activity of the compounds were evaluated by MTT and MIC assays. Compounds 1 and 2 showed promising inhibition on MCF-7 cell line with IC50 of 161.6 and 190.0 A mu M, respectively. Also compounds 2 and 3 illustrated activity against Staphylococcus aureus with MIC values of 142.5 and 136.9 A mu M, respectively.

引用

页码：1055 / 1059

页数：5

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