Isoprenoids from the Soft Coral Sarcophyton glaucum

被引：24

作者：

Chao, Chih-Hua ^{[1
,2
]}

Li, Wen-Liang ^{[3
]}

Huang, Chiung-Yao ^{[3
]}

Ahmed, Atallah F. ^{[4
]}

Dai, Chang-Feng ^{[5
]}

Wu, Yang-Chang ^{[6
,7
,8
]}

Lu, Mei-Chin ^{[9
,10
]}

Liaw, Chih-Chuang ^{[3
]}

Sheu, Jyh-Horng ^{[3
,6
,11
,12
]}

机构：

[1] China Med Univ, Sch Pharm, Taichung 404, Taiwan

[2] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 404, Taiwan

[3] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[4] King Saud Univ, Dept Pharmacognosy, Coll Pharm, Riyadh 11451, Saudi Arabia

[5] Natl Taiwan Univ, Inst Oceanog, Taipei 112, Taiwan

[6] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[7] Kaohsiung Med Univ, Res Ctr Nat Prod & Drug Dev, Kaohsiung 807, Taiwan

[8] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 807, Taiwan

[9] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan

[10] Natl Museum Marine Biol Aquarium, Pingtung 944, Taiwan

[11] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

[12] Natl Sun Yat Sen Univ, Frontier Ctr Ocean Sci & Technol, Kaohsiung 804, Taiwan

来源：

MARINE DRUGS | 2017年 / 15卷 / 07期

关键词：

sarcophyton glaucum; lobocrasol; ent-sarcophyolide E; sarcophine; POLYHYDROXYLATED STEROIDS; BIOACTIVE CEMBRANOIDS; METABOLITES;

D O I：

10.3390/md15070202

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new isoprenoids, 3,4,8,16-tetra-epi-lobocrasol (1), 1,15 beta-epoxy-deoxysarcophine (2), 3,4-dihydro-4 alpha,7 beta,8 alpha-trihydroxy-Delta(2)-sarcophine (3), ent-sarcophyolide E (4), and 16-deacetyl-halicrasterol B (5) and ten known compounds 6-15, were characterized from the marine soft coral Sarcophyton glaucum, collected off Taitung coastline. Their structures were defined by analyzing spectra data, especially 2D NMR and electronic circular dichroism (ECD). The structure of the known compound lobocrasol (7) was revised. Cytotoxicity potential of the isolated compounds was reported, too.

引用

页数：11

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