Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021

被引：79

作者：

Yao, Qifeng ^{[1
,2
]}

Wang, Jie ^{[1
]}

Zhang, Xiaoyong ^{[1
]}

Nong, Xuhua ^{[1
]}

Xu, Xinya ^{[1
]}

Qi, Shuhua ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Trop Marine Bio Resources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol, Guangzhou 510301, Guangdong, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

MARINE DRUGS | 2014年 / 12卷 / 12期

基金：

国家高技术研究发展计划(863计划);

关键词：

Engyodontium album; polyketides; spectroscopic data; cytotoxicity; antilarval; SOUTH CHINA SEA;

D O I：

10.3390/md12125902

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight new chromones, engyodontiumones A-H (1-8), and three new phenol derivatives (9-11) together with eight known polyketides (12-19) were isolated from the deep-sea-derived fungus Engyodontium album DFFSCS021. Their structures were identified by extensive spectroscopic analysis. Compounds 8 and 16 showed significant selective cytotoxicity against human histiocytic lymphoma U937 cell line with IC50 values of 4.9 and 8.8 mu M, respectively. In addition, this is the first time to report that 8, 15 and 16 had mild antibacterial activity against Escherichia coli and Bacillus subtilis, and 15 showed potent antilarval activity against barnacle Balanus amphitrite larval settlement.

引用

页码：5902 / 5915

页数：14

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