The Effect of Morphine on Regional Cerebral Blood Flow Measured by 99mTc-ECD SPECT in Dogs

被引：5

作者：

Adriaens, Antita ^{[1
]}

Peremans, Kathelijne ^{[2
]}

Waelbers, Tim ^{[1
]}

Vandermeulen, Eva ^{[2
]}

Croubels, Siska ^{[3
]}

Duchateau, Luc ^{[4
]}

Dobbeleir, Andre ^{[2
]}

Audenaerts, Kurt ^{[5
]}

Eersels, Jos ^{[6
]}

Vermeire, Simon ^{[2
]}

De Spiegeleer, Bart ^{[7
]}

Polis, Ingeborgh ^{[1
]}

机构：

[1] Univ Ghent, Fac Vet Med, Dept Med & Clin Biol Small Anim, Merelbeke, Belgium

[2] Univ Ghent, Fac Vet Med, Dept Med Imaging Domest Anim, Merelbeke, Belgium

[3] Univ Ghent, Fac Vet Med, Dept Pharmacol Biochem & Toxicol, Merelbeke, Belgium

[4] Univ Ghent, Fac Vet Med, Dept Physiol & Biometry, Merelbeke, Belgium

[5] Univ Ghent, Fac Med & Hlth Sci, Dept Psychiat & Med Psychol, B-9000 Ghent, Belgium

[6] Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands

[7] Univ Ghent, Fac Pharmaceut Sci, Drug Qual & Registrat DruQuaR Grp, B-9000 Ghent, Belgium

来源：

PLOS ONE | 2014年 / 9卷 / 10期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; CYSTEINATE DIMER SPECT; MU-OPIOID RECEPTOR; CONSCIOUS DOGS; NALOXONE; FENTANYL; RAT; REMIFENTANIL; PHARMACOLOGY; METABOLISM;

D O I：

10.1371/journal.pone.0109680

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To gain insights into the working mechanism of morphine, regional cerebral blood flow (rCBF) patterns after morphine administration were assessed in dogs. In a randomized cross-over experimental study, rCBF was estimated with Tc-99m-Ethylcysteinate Dimer single photon emission computed tomography in 8 dogs at baseline, at 30 minutes and at 120 minutes after a single bolus of morphine. Perfusion indices (PI) in the frontal, parietal, temporal and occipital cortex and in the subcortical and cerebellar region were calculated. PI was significantly decreased 30 min after morphine compared to baseline in the right frontal cortex. The left parietal cortex and subcortical region showed a significantly increased PI 30 min after morphine compared to baseline. No significant differences were noted for the other regions or at other time points. In conclusion, a single bolus of morphine generated a changing rCBF pattern at different time points.

引用

页数：5

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