Age-related changes in type-I collagen synthesis in human eyelid skin

被引：7

作者：

DeBacker, CM ^{[1
]}

Putterman, AM ^{[1
]}

Zhou, LL ^{[1
]}

Holck, DEE ^{[1
]}

Dutton, JJ ^{[1
]}

机构：

[1] Duke Univ, Ctr Eye, Durham, NC 27710 USA

来源：

OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY | 1998年 / 14卷 / 01期

关键词：

collagen synthesis; eyelid skin; aging;

D O I：

10.1097/00002341-199801000-00004

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose. This study was to determine whether age-related decrements in type I collagen synthesis occur in human eyelid skin. Methods. Using an antibody to procollagen I, we investigated collagen synthetic activity in skin removed for cosmetic purposes from 10 white patients between the ages of 4 and 77 years. Eleven masked referees graded the immunostaining on a scale of I (most intense) to 10 (least intense). Results. The multiple range test for rank by group demonstrated more intense staining in younger patients compared with older patients. An average correlation coefficient of 0.8432 (p < 0.05) existed between each of the referee's rankings. Conclusion. Type I collagen synthesis diminishes with age in eyelid skin.

引用

页码：13 / 16

页数：4

共 21 条

[1] DERMABRASION - THERAPY AND PROPHYLAXIS OF THE PHOTOAGED FACE [J].