Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome

被引：3

作者：

Streng, Bianca M. M. ^{[1
]}

Bont, Marin ^{[1
]}

Delemarre, Eveline M. ^{[1
,2
]}

Binnendijk, Rob S. ^{[3
]}

Smit, Gaby ^{[3
]}

den Hartog, Gerco ^{[3
]}

Coppus, Antonia M. W. ^{[4
]}

de Vries, Esther ^{[5
,6
]}

Weijerman, Michel E. ^{[7
]}

Lamberts, Regina ^{[7
]}

de Graaf, Gert ^{[8
]}

van der Klis, Fiona R. ^{[3
]}

Vidarsson, Gestur ^{[9
,10
,11
]}

Rave, Neele ^{[1
]}

Bont, Louis J. ^{[1
]}

Wildenbeest, Joanne G. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Paediat Infect Dis & Immunol, POB 85090, NL-3508 AB Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Ctr Translat Immunol, Utrecht, Netherlands

[3] Natl Inst Publ Hlth & Environm, Lab Vaccine Preventable Dis, Bilthoven, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Dept Primary & Community Care, Nijmegen, Netherlands

[5] Tilburg Univ, Tilburg Sch Social & Behav Sci, Tranzo, Tilburg, Netherlands

[6] Jeroen Bosch Hosp, Jeroen Bosch Acad Res, Shertogenbosch, Netherlands

[7] Alrijne Hosp, Dept Pediat, Leiderdorp, Netherlands

[8] Fdn Stichting Down Syndroom, Meppel, Netherlands

[9] Univ Amsterdam, Amsterdam Univ Med Ctr, Sanquin Res & Landsteiner Lab, Amsterdam, Netherlands

[10] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Biomol Mass Spectrometry & Prote, Utrecht, Netherlands

[11] Univ Utrecht, Bijvoet Ctr Biomol Res, Utrecht, Netherlands

来源：

JOURNAL OF INFECTIOUS DISEASES | 2022年 / 226卷 / 04期

关键词：

Down syndrome; antibody response; COVID-19; vaccination; SARS-CoV-2; CHILDREN;

D O I：

10.1093/infdis/jiac235

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The risk of a severe course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults with Down syndrome is increased, resulting in an up to 10-fold increase in mortality, in particular in those >40 years of age. After primary SARS-CoV-2 vaccination, the higher risks remain. In this prospective observational cohort study, SARS-CoV-2 spike S1-specific antibody responses after routine SARS-CoV-2 vaccination (BNT162b2, messenger RNA [mRNA]-1273, or ChAdOx1) in adults with Down syndrome and healthy controls were compared. Adults with Down syndrome showed lower antibody concentrations after 2 mRNA vaccinations or after 2 ChAdOx1 vaccinations. After 2 mRNA vaccinations, lower antibody concentrations were seen with increasing age. In this prospective cohort study that included 222 adults with Down syndrome, a significantly lower antibody response was found after SARS-CoV-2 mRNA or vector vaccination compared to healthy controls. After mRNA vaccination, lower antibodies were found with increasing age.

引用

页码：673 / 677

页数：5

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