Human Milk Microbiome and Maternal Postnatal Psychosocial Distress

被引:51
作者
Browne, Pamela D. [1 ]
Aparicio, Marina [2 ]
Alba, Claudio [3 ]
Hechler, Christine [4 ]
Beijers, Roseriet [1 ,4 ]
Miguel Rodriguez, Juan [2 ]
Fernandez, Leonides [3 ]
de Weerth, Carolina [1 ]
机构
[1] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, Nijmegen, Netherlands
[2] Univ Complutense Madrid, Fac Vet Sci, Dept Nutr & Food Sci, Madrid, Spain
[3] Univ Complutense Madrid, Fac Vet Sci, Dept Sect Galen Pharm & Food Technol, Madrid, Spain
[4] Radboud Univ Nijmegen, Behav Sci Inst, Dev Psychol, Nijmegen, Netherlands
关键词
maternal postnatal psychosocial distress; human milk; milk microbiome; bacterial diversity; time evolution; GUT MICROBIOTA; PSYCHOLOGICAL DISTRESS; PRENATAL STRESS; LATE PREGNANCY; POSTPARTUM; IMPACT; WOMEN; MODE; OLIGOSACCHARIDES; TRANSITION;
D O I
10.3389/fmicb.2019.02333
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Human milk contains many bioactive components, including bacteria, which are transferred to the developing infant through breastfeeding. Milk bacteria appear to, amongst others, originate from the maternal gut. A mother's postnatal psychosocial distress may alter maternal gut microbiota, which in turn may affect the bacteria present in milk. The aim of this study was to explore whether maternal postnatal psychosocial distress was related to alterations in the relative abundances of specific bacteria and to milk microbial diversity. Healthy mothers (N = 77; N = 51 with complete data) collected breast milk samples at 2, 6, and 12 weeks postpartum and filled in mood questionnaires on experienced stress, anxiety, and depressive symptoms at 6 weeks postpartum. A metataxonomic approach (16S rRNA gene sequencing (region V3 and V4) using Illumina MiSeq technology) was used to assess bacterial abundances and diversity. For the group as a whole, an increase in diversity of the milk bacterial community was observed during the first 3 months of breastfeeding (Shannon index). This general increase in diversity appears to be explained by an increase of Lactobacillus and other minor genera, together with a decrease in Staphylococcus. With respect to psychological distress and milk microbial composition, no significant differences in the relative abundance of major bacterial genera were detected between women with high (N = 13) and low (N = 13) psychosocial distress. However, progressive and distinct changes in the content of Firmicutes, Proteobacteria, and Bacteroidetes at the phylum level and Acinetobacter, Flavobacterium, and Lactobacillus at the genera level were observed in milk samples of women with low psychosocial distress. With respect to milk microbial diversity, high maternal psychosocial distress, compared to low maternal psychosocial distress, was related to significantly lower bacterial diversity in milk at 3 months post-delivery. Anxiety, stress, and depressive symptoms separately were unrelated to specific bacterial profiles. The current study suggests a potential relation between maternal psychosocial distress and milk microbiota, providing first evidence of a possible mechanism through which post-partum psychological symptoms may affect infant development and health.
引用
收藏
页数:16
相关论文
共 99 条
[11]  
Boix-Amoros A, 2016, FRONT MICROBIOL, V7, DOI [10.3389/fmicb.2016.00492, 10.5389/fmicb.7016.00492]
[12]   Microbiota in anorexia nervosa: The triangle between bacterial species, metabolites and psychological tests [J].
Borgo, Francesca ;
Riva, Alessandra ;
Benetti, Alberto ;
Casiraghi, Maria Cristina ;
Bertelli, Sara ;
Garbossa, Stefania ;
Anselmetti, Simona ;
Scarone, Silvio ;
Pontiroli, Antonio E. ;
Morace, Giulia ;
Borghi, Elisa .
PLOS ONE, 2017, 12 (06)
[13]   The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery [J].
Cabrera-Rubio, Raul ;
Carmen Collado, M. ;
Laitinen, Kirsi ;
Salminen, Seppo ;
Isolauri, Erika ;
Mira, Alex .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2012, 96 (03) :544-551
[14]   QIIME allows analysis of high-throughput community sequencing data [J].
Caporaso, J. Gregory ;
Kuczynski, Justin ;
Stombaugh, Jesse ;
Bittinger, Kyle ;
Bushman, Frederic D. ;
Costello, Elizabeth K. ;
Fierer, Noah ;
Pena, Antonio Gonzalez ;
Goodrich, Julia K. ;
Gordon, Jeffrey I. ;
Huttley, Gavin A. ;
Kelley, Scott T. ;
Knights, Dan ;
Koenig, Jeremy E. ;
Ley, Ruth E. ;
Lozupone, Catherine A. ;
McDonald, Daniel ;
Muegge, Brian D. ;
Pirrung, Meg ;
Reeder, Jens ;
Sevinsky, Joel R. ;
Tumbaugh, Peter J. ;
Walters, William A. ;
Widmann, Jeremy ;
Yatsunenko, Tanya ;
Zaneveld, Jesse ;
Knight, Rob .
NATURE METHODS, 2010, 7 (05) :335-336
[15]   Gut Microbiota Modification: Another Piece in the Puzzle of the Benefits of Physical Exercise in Health? [J].
Cerda, Begona ;
Perez, Margarita ;
Perez-Santiago, Jennifer D. ;
Tornero-Aguilera, Jose F. ;
Gonzalez-Soltero, Rocio ;
Larrosa, Mar .
FRONTIERS IN PHYSIOLOGY, 2016, 7
[16]   Sex differences in gut microbiota in patients with major depressive disorder [J].
Chen, Jian-jun ;
Zheng, Peng ;
Liu, Yi-yun ;
Zhong, Xiao-gang ;
Wang, Hai-yang ;
Guo, Yu-jie ;
Xie, Peng .
NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2018, 14 :647-655
[17]   Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour [J].
Cryan, John F. ;
Dinan, Timothy G. .
NATURE REVIEWS NEUROSCIENCE, 2012, 13 (10) :701-712
[18]   Physiological Translocation of Lactic Acid Bacteria during Pregnancy Contributes to the Composition of the Milk Microbiota in Mice [J].
de Andres, Javier ;
Jimenez, Esther ;
Chico-Calero, Isabel ;
Fresno, Manuel ;
Fernandez, Leonides ;
Miguel Rodriguez, Juan .
NUTRIENTS, 2018, 10 (01)
[19]   Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling [J].
Deloose, Eveline ;
Tack, Jan .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2016, 310 (04) :G228-G233
[20]   Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB [J].
DeSantis, T. Z. ;
Hugenholtz, P. ;
Larsen, N. ;
Rojas, M. ;
Brodie, E. L. ;
Keller, K. ;
Huber, T. ;
Dalevi, D. ;
Hu, P. ;
Andersen, G. L. .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006, 72 (07) :5069-5072