Higher plasma leptin is associated with higher risk of androgenetic alopecia in men

被引：11

作者：

Yang, Chao-Chun ^{[1
,2
]}

Chung, Pei-Lun ^{[1
]}

Lin, Li-Yu ^{[3
]}

Hughes, Michael W. ^{[2
,4
]}

Tsai, Yau-Sheng ^{[4
]}

机构：

[1] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Dermatol, Tainan, Taiwan

[2] Natl Cheng Kung Univ, Int Res Ctr Wound Repair & Regenerat, Tainan, Taiwan

[3] Yuans Dermatol Clin, Taichung, Taiwan

[4] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Inst Clin Med, Coll Med, Tainan, Taiwan

来源：

EXPERIMENTAL DERMATOLOGY | 2017年 / 26卷 / 06期

关键词：

adipocytes; androgenetic alopecia; body mass index; leptin; transforming growth factor-1; EPITHELIAL-CELL GROWTH; SKIN;

D O I：

10.1111/exd.13369

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In addition to genetics and androgens, novel factors could play a role in androgenetic alopecia (AGA). This study aims to investigate the association between plasma leptin level with the risk and severity of AGA in men. Forty-eight subjects were enrolled including 29 AGA and 19 non-AGA subjects. The plasma leptin level was significantly higher in AGA subjects, compared to non-AGA subjects (4.45 vs 2.76ng/mL, P<.05). A higher plasma leptin levels were positively correlated with the risk of developing AGA in multivariate logistic analysis (odds ratio=2.77, P<.05). Leptin from the circulation might impact the development of AGA.

引用

页码：524 / 526

页数：3

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