Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19)

被引：25

作者：

Anderson, Elizabeth M. ^{[1
]}

Diorio, Caroline ^{[2
,3
]}

Goodwin, Eileen C. ^{[1
]}

McNerney, Kevin O. ^{[2
,3
]}

Weirick, Madison E. ^{[1
]}

Gouma, Sigrid ^{[1
]}

Bolton, Marcus J. ^{[1
]}

Arevalo, Claudia P. ^{[1
]}

Chase, Julie ^{[2
,4
]}

Hicks, Philip ^{[1
,5
]}

Manzoni, Tomaz B. ^{[1
]}

Baxter, Amy E. ^{[6
,7
]}

Andrea, Kurt P. ^{[6
,7
]}

Burudpakdee, Chakkapong ^{[2
]}

Lee, Jessica H. ^{[2
]}

Vella, Laura A. ^{[6
,7
,8
]}

Henrickson, Sarah E. ^{[9
]}

Harris, Rebecca M. ^{[10
]}

Wherry, E. John ^{[6
,7
]}

Bates, Paul ^{[1
,11
]}

Bassiri, Hamid ^{[2
,8
]}

Behrens, Edward M. ^{[2
,4
]}

Teachey, David T. ^{[2
,3
]}

Hensley, Scott E. ^{[1
]}

机构：

[1] Univ Penn, Dept Microbiol, Perelman Sch Med, 402A Johnson Pavil,3610 Hamilton Walk, Philadelphia, PA 19104 USA

[2] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Pediat,Immune Dysregulat Frontier Program, Philadelphia, PA 19104 USA

[3] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Pediat,Div Oncol, Philadelphia, PA 19104 USA

[4] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Pediat,Div Rheumatol, Philadelphia, PA 19104 USA

[5] Univ Penn, Sch Vet Med, Philadelphia, PA 19104 USA

[6] Univ Penn, Perelman Sch Med, Inst Immunol, Philadelphia, PA 19104 USA

[7] Univ Penn, Dept Syst Pharmacol & Translat Therapeut, Philadelphia, PA 19104 USA

[8] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Pediat,Div Infect Dis, Philadelphia, PA 19104 USA

[9] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Pediat,Div Allergy & Immunol, Philadelphia, PA 19104 USA

[10] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[11] Univ Penn, Penn Ctr Res Coronavirus & Other Emerging Pathoge, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | 2021年 / 10卷 / 05期

基金：

美国国家卫生研究院;

关键词：

antibodies; COVID-19; multisystem inflammatory syndrome in children (MIS-C); pediatric; SARS-COV-2;

D O I：

10.1093/jpids/piaa161

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Severe acute respiratory syndrome-coronavirus-2 (SARSCoV-2) antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike immunoglobulin G (IgG) titers compared with those with severe coronavirus disease 2019, likely reflecting a longer time since the onset of infection in MIS-C patients.

引用

页码：669 / 673

页数：5

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