In vitro and in vivo anti-inflammatory properties of green synthesized silver nanoparticles using Viburnum opulus L. fruits extract

被引:76
|
作者
Moldovan, Bianca [1 ]
David, Luminita [1 ]
Vulcu, Adriana [2 ]
Olenic, Liliana [2 ]
Perde-Schrepler, Maria [3 ]
Fischer-Fodor, Eva [3 ]
Baldea, Ioana [4 ]
Clichici, Simona [4 ]
Filip, Gabriela Adriana [4 ]
机构
[1] Babes Bolyai Univ, Fac Chem & Chem Engn, 11 Arany Janos St, RO-400028 Cluj Napoca, Romania
[2] Natl Inst Res & Dev Isotop & Mol Technol, 65-103 Donath St, RO-400293 Cluj Napoca, Romania
[3] Ion Chiricuta Oncol Inst, 34-36 Republicii St, Cluj Napoca 400015, Romania
[4] Iuliu Hatieganu Univ Med & Pharm, Physiol Dept, Cluj Napoca, Romania
来源
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 79卷
关键词
Biosynthesis; Silver nanoparticles; Viburnum opulus L; Anti-inflammatory activity; TOTAL PHENOLS; ANTIBACTERIAL; GILABURU; IL-1-ALPHA; REDUCTION; STORAGE; JUICE; IL-6;
D O I
10.1016/j.msec.2017.05.122
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
A green, rapid and cost effective method for the bio-synthesis of silver nanoparticles (AgNPs), using polyphenols present in European cranberry bush fruit extracts was developed. The obtained AgNPs were characterized by ultra-violet visible spectroscopy (UV-VIS), Fourier transform - infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and X-ray diffraction patterns (XRD). The average size of the spherical AgNPs was found to be 25 nm. The anti-inflammatory effect of the biomaterials was investigated, both in vitro (on HaCaT cell line, exposed to UVB radiation) and in vivo (on acute inflammation model in Wistar rats). Our results support the conclusion that the photosynthesized silver nanoparticles present a potent anti-inflammatory activity and could be successfully used as therapeutic tools for treatment of inflammation. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码:720 / 727
页数:8
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