Donepezil Improves Gait Performance in Older Adults with Mild Alzheimer's Disease: A Phase II Clinical Trial

被引：26

作者：

Montero-Odasso, Manuel ^{[1
,2
,3
,4
]}

Muir-Hunter, Susan W. ^{[1
,2
,3
]}

Oteng-Amoako, Afua ^{[1
,2
]}

Gopaul, Karen ^{[1
,2
]}

Islam, Anam ^{[1
,2
]}

Borrie, Michael ^{[3
]}

Wells, Jennie ^{[3
]}

Speechley, Mark ^{[4
]}

机构：

[1] Parkwood Hosp, Gait & Brain Lab, London, ON, Canada

[2] Lawson Hlth Res Inst, London, ON, Canada

[3] Univ Western Ontario, Schulich Sch Med & Dent, Div Geriatr Med, Dept Med, London, ON N6C 5J1, Canada

[4] Univ Western Ontario, Schulich Interfac Program Publ Hlth, Dept Epidemiol & Biostat, London, ON N6C 5J1, Canada

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2015年 / 43卷 / 01期

基金：

芬兰科学院;

关键词：

Aged; Alzheimer's disease; cholinesterase inhibitors; clinical trials; donepezil; executive function; falls; gait; COGNITIVE ENHANCERS REDUCE; CHOLINESTERASE-INHIBITORS; EXECUTIVE DYSFUNCTION; FALL RISK; DEMENTIA; ATTENTION; VARIABILITY; IMPAIRMENT; PEOPLE; ASSOCIATION;

D O I：

10.3233/JAD-140759

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Gait deficits are prevalent in people with dementia and increase their fall risk and future disability. Few treatments exist for gait impairment in Alzheimer's disease (AD) but preliminary studies have shown that cognitive enhancers may improve gait in this population. Objective: To determine the efficacy of donepezil, a cognitive enhancer that improves cholinergic activity, on gait in older adults newly diagnosed with AD. Methods: Phase II clinical trial in 43 seniors with mild AD who received donepezil. Participants had not previously received treatment with cognitive enhancers. Primary outcome variables were gait velocity (GV) and stride time variability (STV) under single and dual-task conditions measured using an electronic walkway. Secondary outcomes included attention and executive function. Results: After four months of treatment, participants with mild AD improved their GV from 108.4 +/- 18.6 to 113.3 +/- 19.5 cm/s, p = 0.010; dual-task GV from 80.6 +/- 23.0 to 85.3 +/- 22.3 cm/s, p = 0.028. Changes in STV were in the expected direction although not statistically significant. Participants also showed improvements in Trail Making Tests A (p = 0.030), B (p = 0.001), and B-A (p = 0.042). Conclusion: Donepezil improved gait in participants with mild AD. The enhancement of dual-task gait suggests the positive changes achieved in executive function as a possible causal mechanism. This study yielded a clinically significant estimate of effect size; as well, the findings are relevant to the feasibility and ethics considerations for the design of a Phase III clinical trial.

引用

页码：193 / 199

页数：7