ANTIMICROBIAL ACTIVITY SCREENING OF SOME HYDRAZINECARBOTHIOAMIDES AND HETEROCYCLIC COMPOUNDS

In this paper we present the antimicrobial activity screening of a series of eighteen compounds from hydrazinecarbothioamides (1-3), 1,2,4-triazole-3-thiones (4-6), S-alkylated 1,2,4-triazoles (7-12), 1,3,4-thiadiazoles (13-15) and 1,3,4-oxadiazoles (16-18) class which contain arylsulfonylphenyl and 2,4-difluorophenyl moieties in their molecule. The antimicrobial action of these compounds has been investigated against the following reference microbial strains: Escherichia coli ATCC 25922, Enterobacter cloacae ATCC 49141, Acinetobacter baumannii ATCC 19606, Pseudomonas aeruginosa ATCC 27853, Bacillus cereus ATCC 13061, Staphylococcus aureus ATCC 29213, Candida albicans ATCC 90028, Candida glabrata ATCC 64677, Candida krusei ATCC 14243 and Candida parapsilosis ATCC 22019, by the broth microdilution method. Comparing the values of the minimum inhibitory concentrations of the compounds it was noticed that triazoles 4-6 and hydrazinecarbothioamide 2 had in general the best antibacterial activity against some tested bacteria (MIC of 32 mu g/mL) and oxadiazole 17 showed the best antifungal activity against C. parapsilosis (MIC of 32 mu g/mL).