Serum uric acid levels in obese patients with metabolic syndrome

Purpose: The aim of this study was to determine the frequency of metabolic syndrome in obese patients and evaluate serum uric acid levels in obese patients with metabolic syndrome. Materials and Methods: The retrospective study included 270 obese patients with follow-up at the Obesity Center of Health Sciences University Antalya Training Research Hospital between November 2018 and February 2020. Patients who were divided into two groups with and without metabolic syndrome were compared in terms of serum uric acid levels. Results: Of the patients 92,6% were female and 7,4% were male. The average age was 51,8 +/- 9,6 years. 141 patients (52,22%) had metabolic syndrome. Weight, body mass indexe, waist/hip ratio were significantly higher in patients with metabolic syndrome. In addition to metabolic syndrome parameters, glycosylated hemoglobin, fasting insulin, insulin resistance and uric acid levels were also significantly higher in the group with metabolic syndrome. A statistically significant positive correlation was found between uric acid and waist circumference, fasting insulin and insulin resistance in patients with metabolic syndrome. Multivariate logistic regression analysis showed that uric acid increased the risk of metabolic syndrome regardless of other parameters. Conclusion: The frequency of metabolic syndrome increases in obese patients, and serum uric acid levels increase in obese patients accompanied by metabolic syndrome. In addition, there is a positive correlation between serum uric acid levels and waist circumference and insulin resistance in these patients. Especially obese patients with metabolic syndrome accompanying with abdominal obesity and insulin resistance should be screened for hyperuricemia, which is considered as a cardiovascular disease risk marker.