Left Renal Cortical Thickness Measured by Ultrasound Can Predict Early Progression of Chronic Kidney Disease

被引：30

作者：

Takata, Tomoaki ^{[1
]}

Koda, Masahiko ^{[1
]}

Sugihara, Takaaki ^{[1
]}

Sugihara, Shinobu ^{[2
]}

Okamoto, Toshiaki ^{[1
]}

Miyoshi, Kenichi ^{[1
]}

Hodotsuka, Masanori ^{[1
]}

Fujise, Yuki ^{[1
]}

Matono, Tomomitsu ^{[1
]}

Okano, Junichi ^{[1
]}

Hosho, Keiko ^{[1
]}

Iyama, Takuji ^{[1
]}

Fukui, Takeaki ^{[1
]}

Fukuda, Satoko ^{[1
]}

Munemura, Chishio ^{[1
]}

Isomoto, Hajime ^{[1
]}

机构：

[1] Tottori Univ, Fac Med, Div Med & Clin Sci, Tottori 680, Japan

[2] Tottori Univ, Fac Med, Div Mol Med & Therapeut, Tottori 680, Japan

来源：

NEPHRON | 2016年 / 132卷 / 01期

关键词：

Chronic renal disease; Japan; Noninvasive; Renal size; Renal ultrasonography; ISCHEMIC NEPHROPATHY; ULTRASONOGRAPHY; ALLOGRAFT; AGE;

D O I：

10.1159/000441957

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: The kidney becomes atrophic in advanced chronic kidney disease, and renal size and parenchymal volume correlate with renal function. However, alterations in renal parenchymal volume have not been adequately studied in terms of the renal cortex and medulla. We investigated the relationship between the changes in the renal cortex and medulla and renal function. Methods: Renal ultrasound (US) parameters including renal length, parenchymal thickness, cortical thickness and medullary thickness were assessed in 176 subjects, who were categorized into 4 groups based on the estimated glomerular filtration rate (ml/min/1.73 m(2)): group 1, >= 90; group 2, >= 6.0 but <90; group 3, >= 30 but <60; and group 4, <30. Renal US parameters in both kidneys were compared among the 4 groups. Results: We found stepwise associations in renal length, cortical thickness and parenchymal thickness with decreased renal function. Medullary thickness showed no changes among groups 1-3. Multiple linear regression analysis including sex, age and renal US parameters showed that only renal length was an independent predictor of renal function. When analyzed in groups 1-3, cortical thickness was the strongest associated parameter. Lower cortical left/right ratio (left cortical thickness/right cortical thickness) showed a stepwise association with a decrease in renal function. Conclusion: Renal length and cortical thickness measured by US were correlated with renal function. In particular, left cortical thickness could help to detect early changes in renal function. (C) 2015 S. Karger AG, Basel

引用

页码：25 / 32

页数：8

共 26 条

[21] Structure, not just function [J].