Innovation driven development is the demand of the times, leaders of new era need extraordinary innovation ability, advanced strategic decision-making ability and powerful influence output ability. On the base of recent research in students' leadership education, this paper constructs a conceptual model of leadership education - Innovation-Driven Model-specially for universities of science and engineering. This model points out, to cultivate the science and engineering universities' students' leadership, the cultivate direction is "innovation-driven leadership", the cultivate method is "stereoscopic personalized supply", the cultivate condition is constructing "ecosystem of educational resources" and the cultivate power is constructing "dynamic feedback regulation system". Apply this model into practice at UESTC-a students' leadership cultivation system called "UESTC's Dong Liang Project", integrating an educational resource platform which includes teaching resources, project resources and base resources, and formulating three layering projects named "Pioneer-Project" "Elite-Project" and "Excellent-Project" according to the development status of students' leadership and creativity. This model takes both the characteristics of students of science and engineering universities and the actual needs of social development into consideration, fully respects the needs of students, consider both education efficiency and education fairness, and has achieved some success in practice.